Final File_Top 5 Visionary Top 5 Advancing Healthcare Industry - 2025-compressed

Top 5 Visionary Leads Advancing Healthcare Industry - 2025 Data to Decisions The Rise of Predictive Healthcare Leadership Human Touch in a Tech Driven Era Reimagining Compassionate Healthcare Kuroyama Designing Pathways for Treatments Without Trails

Science can't grant immortality, but it can offer something just as profound: more time to be human.

N O T E PUBLISHER: WORLD CARE MAGAZINE Honoring the Visionaries of Modern Healthcare Managing Editor Art and Design Head Business Development Kevin Smith T Nicole Wilson Jack Miller, Michael Brown, Melissa Anderson, Ashley Thompson here are few callings as noble as the pursuit of healing. Within every heartbeat, every cure, and every moment of compassion lies the essence of what it means to serve humanity. Healthcare is more than science and skill. It is the quiet courage of those who stand between pain and hope, the unwavering commitment to restore balance where life falters. In an age where technology and medicine intertwine, this calling has evolved into a mission that unites intellect, empathy, and innovation. The true spirit of healthcare is not just in saving lives but in redefining how life itself can be lived with dignity, health, and grace. Executives Marketing Manager Technical Head Digital Marketing Manager Circulation manager Grace Jackson Luca Ferrari Sophia Rossi Henry Scott Alexander Marinov This edition, Top 5 Visionary Leaders Advancing Healthcare Industry – 2025, celebrates those who stand at the forefront of this evolution. These are the pioneers who see beyond the confines of traditional medicine. They merge human understanding with intelligent systems, reshaping the boundaries of care delivery, accessibility, and efficiency. Their leadership reflects the heart of progress, reminding us that the future of healthcare depends not only on technology but on the wisdom and compassion guiding its use. Through their vision, they transform hospitals into ecosystems of healing, data into foresight, and science into service. , , Accounts , , As we look to the future, the path ahead holds immense promise. Artificial intelligence, genomics, and personalized medicine are opening possibilities once thought unreachable. Yet amid all technological brilliance, it is the human touch that will define the next era of healthcare. The future will belong to those who combine innovation with integrity, foresight with compassion, and progress with purpose. Through the vision of these remarkable leaders, the story of healing continues, ever evolving, ever inspiring, and ever devoted to the timeless pursuit of life itself. Innovation in healthcare is not about fixing broken things, it's about creating something better. Contact Us: Michael Brown michael@worldcaremagazine.com WhatsApp: +44 204 577 4296 | +1 307 314 9695 - Elizabeth Holmes - Kevin Smith Managing Editor

Cover Story Table of Shoji Kuroyama 06 Designing Pathways Dr Minshad Ansari for Treatments Revitalising the Heart of Agriculture Without Trails 16 The Rise of Regenerative Medicine 26 22 32 What's Next for Treating Age-Related Degenerative Diseases? Dr. Yaser Moshref Shaping the Future of Longevity and Preventive Wellness Worldwide Jesse Bethke Gomez Human Touch in a Tech Driven Era Reimagining Transforming Healthcare Crafting a Legacy of The Convergence of Dave Vigerust Data to Decisions Compassionate Healthcare Through Personalized Dignity in Direct Care MedTech and Pharma Medicine and Innovation Profile Articles

Kuroyama Designing Pathways for Treatments Without Trails In rare diseases, every decision matters. You may not have the luxury of scale, but you always have the responsibility to make each case count. www.worldcaremagazine.com www.worldcaremagazine.com 06 07

Evolution from Rep to Regional Visionary understanding of operational details and strengthened his appreciation for the efforts of his team. Shoji began his career in 1994 as a sales representative in the Pharmaceutical Division of Kirin. He later moved into the Marketing Department, where he served as a Product Manager. After earning his MBA in New York, he joined Janssen Pharmaceuticals. There, he played a pivotal role in developing and expanding the oncology business, especially in hematologic malignancies. His responsibilities gradually grew to include new therapeutic areas, hepatitis C, new product planning, and the integration of Actelion into Janssen Japan. His time in Singapore also gave him valuable insight into leading without formal authority. By collaborating with multiple country organizations as a facilitator rather than a top-down leader, Shoji honed his ability to influence and drive results through collaboration. Overall, his career journey has given him a well-rounded leadership style built on personal growth and leveraging diverse strengths. D Strategic Lens on Therapeutic Leadership espite extraordinary advances in medicine, certain voices remain faint in the corridors of care. Among them are individuals living with rare diseases, patients whose conditions are so uncommon they often fall outside the reach of conventional treatment models. These are not just medical outliers; they are children, parents, and communities waiting for answers that rarely come. Their conditions may be few in number, but their need for treatment is no less critical. Traditional healthcare systems, built to serve the many, often struggle to accommodate the few. And in that silence, the need for focused, purposeful intervention becomes not just important, but essential. At Janssen, Shoji also took on the role of Asia-Pacific Regional Lead for Oncology and Hematology, based in Singapore. Following that, he joined Incyte and spent four years building the foundation for the commercial team to support the launch of a biliary tract cancer product in Japan. Shoji's leadership across oncology, hematology, and infectious diseases in both Japan and the Asia-Pacific region has shaped a practical and principle- driven view of leadership. When it comes to business models, he notes that the fundamental approach does not drastically change across therapeutic areas. Whether the focus is hematology, infectious disease, or rare diseases, success typically hinges on three core elements—targeting the right audience, delivering the right message, and maintaining strong communication with healthcare professionals. Throughout his career, Shoji gained a wide range of experiences that shaped him as both a technical expert and a leader. As a marketer, he learned to simplify complex messages for sales teams and to use logic effectively. His career also taught him how to handle uncertainty and build new business operations from scratch. These challenges strengthened his flexibility, helped him avoid perfectionism, and inspired him to challenge the status quo. He also observes that pricing strategies tend to follow common methodologies, such as comparator-based or cost- based calculations, particularly in Japan. While access frameworks and reimbursement systems can vary between countries, the overarching business logic remains consistent. Shoji Kuroyama has made it his mission to close that gap. From his early days as a sales representative to his current role as President of Recordati Japan, Shoji has redefined what it means to lead with precision and purpose. His journey has spanned continents, therapeutic areas, and business functions, but the throughline is clear, a commitment to bringing critical therapies to those most often left behind. At Incyte Japan, Shoji worked in a lean structure that required hands-on involvement across various functions. He personally led initiatives such as press releases, media seminars, and pricing negotiations with the Ministry of Health. This exposure deepened his In drug development, rare diseases may involve slightly different strategies. For example, in ultra-rare conditions, a smaller data set—perhaps www.worldcaremagazine.com www.worldcaremagazine.com 08 09

just a Phase I/II study in Japan along with global pivotal data, may be sufficient for approval. In all these ways, Shoji is ensuring that the philosophy of "Focused on the Few" is more than just a slogan, it's a guiding principle embedded in the team's daily operations. Drawing from his extensive experience across diverse therapeutic areas, Shoji feels confident leading in the rare disease space. At its core, he believes that a solid, fundamentals-based business model remains effective regardless of the therapeutic category. Building a Strong Foundation for Rare Disease Leadership In his first year as President, Shoji's immediate strategic priorities center on maximizing the value of Recordati's current pipeline in the Endocrinology/Metabolic and Hematology/Oncology business units. At the same time, the company is focused on acquiring rights to new compounds that can both offset potential drug loss and meet high unmet medical needs in the rare disease space. Bringing "Focused on the Few" to Life Shoji is deeply committed to turning Recordati's philosophy of "Focused on the Few" into practical and meaningful actions. First, the Japan team ensures appropriate product use by providing accurate, timely information to healthcare professionals through webinars and in-person interactions. This supports patients with rare diseases by equipping clinicians with the knowledge they need. To achieve these goals, Shoji emphasizes the importance of enhancing Recordati's presence and becoming the partner of choice for patients, caregivers, healthcare professionals, partner companies, and employees. A key enabler of this vision is talent, specifically, attracting and retaining top talent within the organization. Shoji believes the company is on the right trajectory, building a workplace culture that supports both innovation and collaboration. Second, the team's licensing-in strategy emphasizes innovative products in the rare disease space. This helps mitigate the risk of drug unavailability in Japan, ensuring patients have continued access to essential treatments. Third also refers to the team itself. Compared to other mid-sized companies, Recordati Japan is a lean organization. This creates a unique opportunity to foster inclusivity and responsiveness. Shoji and his team actively listen to employee feedback and build a workplace where voices are heard and valued. Evolving Access in Japan's Drug Landscape Shoji acknowledges that the rare disease market in Japan continues to evolve, supported by incentives such as www.worldcaremagazine.com www.worldcaremagazine.com 010 011

therapies can reach patients in Japan more quickly and effectively. can, in itself, increase awareness and shift societal and clinical perceptions — helping to foster earlier diagnosis and stronger support systems around patients. Education, Innovation, and Early Detection A Personal Commitment to Patient- Centricity Shoji believes that one of the most urgent challenges in rare disease care is the long and often arduous journey patients face before receiving a diagnosis and treatment. To address this, he emphasizes the importance of improving disease awareness, particularly around the burden of rare diseases and the critical role early diagnosis plays in patient outcomes. Recordati Japan remains committed to advancing medical education programs as a key tool in supporting this objective. For Shoji, patient centricity is not a slogan, it is a deeply personal conviction shaped by pivotal moments in his career. Early on, he admits he lacked a full understanding of what it truly meant to be patient-centric. But while working at Janssen as a product manager for a targeted therapy for multiple myeloma, he witnessed firsthand how a breakthrough drug could dramatically improve not only prognosis but also a patient's quality of life. Orphan Drug designation from the Ministry of Health, Labour and Welfare. These designations typically offer protection from NHI price reductions and generic competition, making the market attractive for pharmaceutical companies. However, Shoji also underscores that the company's highest priority is bringing new, innovative therapies to the Japanese market. He believes that the presence of effective treatments However, he points out a growing concern: drugs targeting ultra-rare diseases, with very small peak sales potential, often fail to attract sufficient interest from industry players. This poses a risk of drug loss and access challenges for patients. That experience became a turning point. Since then, Shoji has been unwavering in his mission to deliver In response to these concerns, regulatory bodies such as the PMDA have introduced progressive frameworks designed to ease market entry. One notable example is the conditional approval system, which allows marketing authorization based on Phase I/II data, provided that confirmatory studies, such as Phase III trials, are conducted post-launch. This system significantly lowers the entry barrier for small- and mid-sized biotech firms that may lack the funding or resources for large-scale trials upfront. My vision is to make Recordati the company people think of first when they talk about rare diseases in Japan, not just because of our products, but because of our purpose. Shoji sees this regulatory innovation as a critical enabler of growth in the rare disease sector. He hopes that such initiatives will continue to be developed, ensuring that innovative www.worldcaremagazine.com www.worldcaremagazine.com 012 013

innovative therapies to as many patients as possible, aiming to transform lives through access to science. At Recordati Japan, he actively embeds this principle into the company culture, including hosting "patient voice" sessions during company kick-off meetings to ensure that every employee, across both commercial and R&D teams, is reminded of the people they ultimately serve. engagement, he emphasizes, is a critical success factor that data alone cannot replace. Encouraging Voices in the Japanese Workforce Having worked in both Japan and Singapore across various therapeutic areas, he draws meaningful contrasts in leadership and communication styles. In his experience, Asia-Pacific employees are often proactive in career development and confident in sharing their strengths. In Japan, however, a culture of humility can sometimes limit individuals from seizing growth opportunities. Learning from his time abroad, he has made a conscious effort to adopt a more assertive and strategic approach to career and business growth, advocating for a mindset shift that encourages Japanese professionals to showcase their capabilities more openly. perspectives of KOLs on epidemiology, treatment algorithms, and unmet needs are invaluable for strategic planning and negotiations. Equally important, he believes, is maintaining a deep understanding of regulatory expectations and fostering timely, frequent engagement with the PMDA. These relationships are critical not only for streamlining drug filings but also for combating the growing issue of drug attrition in the Japanese market. A Story That Fuels Purpose Among the many patient and caregiver stories Shoji has encountered over the years, one in particular has left a lasting impact. Through a patient advocacy group, he learned about a family affected by hyperammonemia, a rare condition that can strike in early infancy. In this heartbreaking case, delayed diagnosis led to irreversible intellectual disabilities in a young child. Lessons in the Rearview The Drive Behind Recordati's Pipeline The story, Shoji says, was both shocking and deeply moving. It highlighted the devastating cost of late intervention and reinforced his resolve to drive awareness and access in Recordati's key therapeutic areas. For Shoji, preventing such tragedies is not just a professional goal — it is a personal mission that continues to guide his leadership every day. Reflecting on more than two decades in the pharmaceutical industry, he would advise his younger self to never stop working hard. Consistency, perseverance, and learning from failure, he believes, are the foundations for long-term success. He encourages trusting the process and believing in one's potential. He finds deep motivation in Recordati's current pipeline, which is centered on rare diseases. While patient numbers may differ by treatment in Japan, the consistent factor that excites him is the strong sense of purpose and contribution to patients' lives. For him, working in the rare disease space offers a unique opportunity to make a meaningful impact where it matters most. What continues to inspire him today is the people around him, his team, and external stakeholders. He emphasizes that success is never a solo achievement; it's the result of shared commitment, collaboration, and a united drive to improve patients' lives. Blueprint for People-Centered Success KOLs and Regulators as Catalysts for Innovation He places deep value on emotional intelligence in leadership, especially in an industry driven by data, regulation, and science. For him, people are the true driving force behind success. He believes that how passionately employees connect with the organization's mission—improving patients' lives, is what ultimately propels a company forward. Emotional He envisions that key opinion leaders (KOLs) and Japan's Pharmaceuticals and Medical Devices Agency (PMDA) will play increasingly pivotal roles in accelerating innovation. As Recordati brings new drugs from small biotech firms in the US and EU to Japan, the www.worldcaremagazine.com www.worldcaremagazine.com 014 015

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Data to Decisions The Rise of ealthcare stands at a remarkable turning H become a living source of insight capable of shaping decisions before events unfold. From predicting disease outbreaks to optimizing hospital resources, data has transformed from a tool of observation into a guide for action. At the heart of this transformation stands a new generation of leaders who are using predictive intelligence to make healthcare more proactive, personalized, and precise. Predictive healthcare leadership represents a powerful shift from managing what has happened to anticipating what will happen and acting before it does. models that continuously learn from new information. This capability allows healthcare professionals to move from a reactive model of care to a preventive one. Instead of waiting for patients to fall ill, predictive systems help doctors intervene early, saving lives and reducing costs. point where information is no longer confined to reports and records. It has Leaders at the Forefront of Intelligent Healthcare Predictive healthcare leadership is not about replacing human judgment with algorithms. It is about empowering leaders to make informed decisions based on intelligent insights. These leaders combine medical knowledge with data science, ethics, and strategy to guide their organizations toward efficiency and empathy. They understand that technology is most effective when paired with vision, responsibility, and human understanding. The Power of Prediction in Modern Medicine Predictive analytics uses historical and real-time data to forecast future outcomes. It draws from electronic health records, genomic data, wearable devices, and even social factors to identify patterns that reveal emerging risks. A patient's vital signs, lifestyle habits, and medical history can now be analyzed to predict conditions such as diabetes, heart disease, or stroke long before symptoms appear. Hospitals use these insights to allocate staff and resources efficiently, preventing delays in treatment and improving patient outcomes. Forward thinking hospital administrators are adopting predictive models to monitor patient flow, forecast demand for medical supplies, and identify potential bottlenecks. Clinical leaders are using AI powered analytics to detect disease progression patterns and personalize treatments. Public health officials are leveraging data to anticipate epidemics and deploy resources before crises escalate. Each of these actions demonstrates how leadership rooted in prediction transforms not only systems but entire communities. What once required years of observation can now be achieved in minutes through machine learning www.worldcaremagazine.com www.worldcaremagazine.com 022 023

From Information to Intelligence patients, professionals, and society. They will need to translate complex insights into clear strategies, bridging the gap between technology experts and clinical teams. Leadership in this field is as much about communication and collaboration as it is about computation. The difference between data and decision lies in interpretation. Predictive healthcare leadership bridges that gap by transforming raw information into actionable intelligence. It involves asking the right questions, defining relevant metrics, and ensuring that insights align with patient needs and ethical values. Conclusion: Shaping the Future of Healthcare Leadership For example, predictive models can highlight which patients are at high risk of readmission after discharge. Leaders can then implement follow up programs or community support systems to prevent unnecessary hospital visits. Similarly, analyzing data from wearable devices can help identify population wide health trends, guiding preventive campaigns and wellness initiatives. These strategies reduce the burden on healthcare systems while improving overall quality of care. The journey from data to decision is redefining healthcare. Predictive leadership transforms uncertainty into opportunity by giving organizations the foresight to act with purpose and precision. Hospitals can anticipate challenges before they arise, policymakers can plan more effectively, and doctors can treat patients before illnesses advance. Yet the most powerful aspect of predictive healthcare lies not in algorithms but in awareness. The awareness that data is only as meaningful as the intent behind its use. The future of healthcare leadership will depend on those who can unite technology with ethics, analytics with empathy, and prediction with human judgment. Ethics and Trust in the Predictive Age As data becomes more central to healthcare, issues of privacy, consent, and ethical responsibility take center stage. Predictive systems often rely on sensitive personal information, and misuse can undermine public trust. Responsible leaders ensure that patient confidentiality remains a top priority while maintaining transparency about how data is used. As the world moves deeper into the age of intelligent insight, leaders who harness prediction responsibly will shape a future where care is not just reactive but truly preventive. The evolution of healthcare will no longer be about responding to illness but nurturing wellness guided by data, driven by compassion, and led by vision. Ethical leadership also means questioning the limits of prediction. While algorithms can suggest probabilities, they cannot replace empathy or moral reasoning. Healthcare leaders must balance data-driven efficiency with human compassion, ensuring that technology serves humanity rather than the other way around. Predictive insights should guide decisions but never dictate them. Training the Next Generation of Predictive Leaders The rise of predictive healthcare calls for a new kind of leadership that is fluent in both science and empathy. Educational institutions are beginning to merge data analytics with healthcare management, preparing future leaders to interpret data responsibly and use it to inspire positive change. These emerging leaders must understand not only how predictive models work but also how they impact www.worldcaremagazine.com www.worldcaremagazine.com 024 025

Human Touch in a Tech Driven Era Reimagining Compassionate Healthcare T echnology has become the heartbeat of modern healthcare, reshaping how patients are diagnosed, treated, and cared for. Artificial intelligence, robotics, telemedicine, and data analytics are no longer distant ideas; they are essential instruments in hospitals and clinics worldwide. Yet as innovation accelerates, a vital question emerges. Can the warmth of human care survive in a system increasingly powered by machines? The answer lies not in choosing between compassion and technology but in weaving them together to create a more humane and intelligent form of healing. future must blend innovation with emotional intelligence. Machines may guide decisions, but it is compassion that heals hearts. Modern healthcare leaders recognize this balance as the foundation of meaningful progress. Hospitals now use technology not to replace empathy but to enhance it. For instance, virtual care platforms connect patients with doctors across distances, but physicians are trained to maintain presence through tone, attention, and understanding. Similarly, automation in routine tasks allows caregivers to spend more time with patients, offering comfort that no algorithm can replicate. Where Machines Meet Humanity Designing Compassion into Technology Compassion is the oldest medicine known to humankind. It is the gentle hand that reassures, the empathetic voice that comforts, and the understanding that brings hope in moments of pain. While technology can analyze symptoms, scan the body, and predict outcomes, it cannot truly sense human emotion. A machine can detect a heartbeat but cannot understand a breaking one. This difference highlights why the healthcare of the Empathy can be engineered into healthcare systems through thoughtful design and intentional innovation. This movement, known as compassionate technology, seeks to ensure that digital tools serve emotional as well as physical needs. For example, hospital apps now feature calming colors, supportive language, and personalized guidance to www.worldcaremagazine.com www.worldcaremagazine.com 032 033

reduce patient anxiety. In elder care, robotic companions are programmed to recognize emotional cues and respond with comforting gestures or words. Even the design of healthcare spaces is evolving, with natural light, soothing sounds, and warm visuals supporting mental and emotional well-being. cultures are finding that empathy revitalizes the entire system. A cared-for caregiver is more capable of caring for others. Conclusion: The Future of Healing The healthcare of the future will be defined not by how advanced its machines become, but by how deeply it remembers its purpose,to heal both body and spirit. The human touch must not fade amid innovation; it must evolve alongside it. Technology can diagnose, predict, and measure, but only compassion can comfort, reassure, and connect. As we move forward, the most successful systems will be those that unite data with dignity, precision with empathy, and progress with humanity. The future of compassionate healthcare is not a choice between science and soul. It is a promise to honor both, ensuring that even in the most digital age, care remains profoundly human. Behind these innovations are leaders who believe compassion is not separate from efficiency; it enhances it. When technology reduces stress and fosters trust, patients recover faster, doctors perform better, and healthcare outcomes improve. This harmony between empathy and advancement defines the future of care. Ethics, Trust, and the Soul of Healthcare As digital transformation deepens, compassion must extend beyond patient interaction to include how data and technology are managed. Electronic health records, predictive algorithms, and AI-driven diagnostics all carry great responsibility. Compassion in this context means respecting privacy, being transparent about data use, and maintaining fairness in algorithmic decisions. Healthcare cannot afford to lose trust in the pursuit of speed or convenience. Ethical innovation ensures that technology serves humanity, not the other way around. Training programs and medical schools are adapting to this reality. Future healthcare professionals are taught not only to master technology but also to preserve empathy while doing so. Emotional intelligence and communication are now as important as clinical skill. The physicians of tomorrow will use AI to guide decisions, yet they will still look into a patient's eyes with reassurance, proving that true care comes from both knowledge and kindness. Healing the Healers Compassion is not only for patients, it is for those who serve them. Doctors, nurses, and healthcare staff often face burnout from long hours, emotional exhaustion, and the weight of human suffering. Technology, when used wisely, can restore balance. Automating repetitive documentation and routine analysis it allows professionals to focus on meaningful patient interaction. Hospitals that integrate wellness programs, digital mindfulness tools, and supportive leadership www.worldcaremagazine.com www.worldcaremagazine.com 034 035

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Healthcare Magazine That Heals and Inspires The World Care Magazine is dedicated to exploring cutting-edge innovations, inspiring leadership, and remarkable stories from the world of healthcare. We bring together industry experts, pioneers, and in?uencers who are shaping the future of healthcare. Stay informed, stay inspired, and be part of the transformation. Contact Us: Michael Brown Email: michael@worldcaremagazine.com WhatsApp: +44 204 577 4296 | +1 307 314 9695

Final File_Top 5 Visionary Top 5 Advancing Healthcare Industry - 2025-compressed

Final File_Top 5 Visionary Top 5 Advancing Healthcare Industry - 2025-compressed

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