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Spasticity in Cerebral Palsy Pathophysiology to practice. By: Hamidah Lalani, BSN, RN. Graduate Student Alverno College. Objectives. The learner will be able to: Understand the functions of upper motor and lower motor neurons
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By: Hamidah Lalani, BSN, RN.
Injury to UMN leads to hypertonia.
Elicit deep tendon reflex
Dorsal horn cell in spinal column carry information to the brain and are also called afferent nerve fibers or input association (IA).
Lower motorneuron Injury or lesion to LMN results in hypotonia.
Have negative reflexes.
Ventral horn cells in spinal column bring information to the muscle fibers and are also called efferent nerve fibers or output association (OA).
In the event of an inflammatory immune response, the brain cells including neurons produce broad spectrum inflammatory mediators like CRP and cytokines IL-1B and IL6 that can cause tangles and plaques which could in turn cause neuronal loss and ultimately loss of movement.
CPK IL- IB, IL- 6
CPK IL- 6
CPK IL- IB
Reticular activating system
Cortical releasing factor
It is the tension in a muscle caused by the passive movement of the joint and it is very important for the muscle movement.
Intrafusal muscle fibers lengthens the the muscle.
Extrafusal muscle fibers contracts the muscle.
Stretch the muscle
Contract the muscle
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