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Outline of Bioinorganic Chemistry. Chapter 1 Introduction Chapter 2 Alkali and Alkaline Earth Metals Chapter 3 Metalloproteins and Metalloenzymes Chapter 4 Bioinorganic Chemistry of Nonmetallic Inorganic Compounds Chapter 5 The Frontiers of Bioinorganic

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outline of bioinorganic chemistry
Outline of Bioinorganic Chemistry

Chapter 1 Introduction

Chapter 2 Alkali and Alkaline Earth Metals

Chapter 3 Metalloproteins and Metalloenzymes

Chapter 4 Bioinorganic Chemistry of Nonmetallic

Inorganic Compounds

Chapter 5 The Frontiers of Bioinorganic

Chemistry

chapter 1 introduction
Chapter 1 Introduction

1. What is Bioinorganic Chemistry?

2. Inorganic Elements in Biological Systems

3. Biological Ligands (Biologically Important Compounds)

4. Experimental Methods (Physicochemical Methods and Biological Methods)

1 1 what is bioinorganic chemistry
1.1 What is Bioinorganic Chemistry?

1.1.1 Bioinorganic Chemistry is a leading discipline at the interface of chemistry and biology

  • Many critical processes require metal ions, including respiration, much of metabolism, nitrogen fixation, photosynthesis, development, nerve transmission, muscle contraction, signal transduction, and protection against toxic and mutagenic agents.
  • Synthetic Chemists, Spectroscopists, Electrochemists, Theoreticians, Biochemists, and molecular Biologists meet at the frontiers of chemistry and biology and are challenged by exciting problems.
1 1 2 development of bioinorganic chemistry
1.1.2 Development of Bioinorganic Chemistry

Molecule, Cell, and Humanity

elements small molecules amino acids,

nucleotides,carbohydrates, fatty acids

protein(enzymes), lipids, poly-carbohydrates

poly-nucleotides metalloproteins

(metalloenzymes), other macromolecules

procaryocyte, eucaryocyte bacteria,

microorganisms, plants, animals, humanity

slide5

The first symposium on bioinorganic chemistry was initiated by inorganic chemists in 1970

The first book called “ Bioinorganic Chemistry” was written by 45 authors and published in 1973

1 1 3 current situation
1.1.3 Current Situation

Inorganic Biochemistry: An Introduction

James A. Cowan

The Ohio State University 1993, 1997

Principles of Bioinorganic Chemistry

Stephen J. Lippard

Maqssachusett Institute of Technology

Jeremy M. Berg

John Hopkins School of Medicine

the international conference on biological inorganic chemistry
The International Conference on Biological Inorganic Chemistry
  • 1983 in Florence, Italy
  • 1985 in the Algarve, Portugal
  • 1987 in Noordwijkerhout, The Netherlands
  • 1989 in Cambridge, USA
  • 1991 in Oxford, UK
  • 1993 in La Jolla, USA
  • 1995 in Lubeck, Germany
  • 1997 in Yokohama, Japan
  • 1999 in Minneapolis, Minnestoa
5 th international symposium on applied bioinorganic chemistry
5th International Symposium on Applied Bioinorganic Chemistry
  • Metalloenzymes - Model Compounds
  • Biomaterials – Bioelectronics
  • Metal Based Drugs – Metals in Medicine
  • Metals Toxicology and Metals in the Environment
  • Metal Interaction with DNA and RNA Constituents
  • Spectroscopic Applications
slide9
J. Am. Chem. Soc
  • Biochemistry
  • Chem. Rev
  • Acc. Chem. Res.
  • Annual Reports on the Progress of Chemistry
  • Nature
  • Science
  • J. Inorg. Biochem
1 2 inorganic elements in biological systems
1.2 Inorganic Elements in Biological Systems
  • Bulk Elements: O, C, H, N, Ca, S, P,

Na, K, Cl, Mg, etc.

  • Trace Elements: Mo, Mn, Fe, Co, Cu,

Zn, I, Si, etc.

  • Ultra-trace Elements: V, Cr, Se, Br, Sn,

F, etc.

1 3 biological ligands
1.3 Biological Ligands
  • Proteins, Carbohydrates, Lipid, Steroids, Nucleotides
  • Prosthetic Groups
  • Coenzyme B12
  • Bleomycin and Siderophores
  • Complex Assembies
1 4 methodology
1.4 Methodology
  • Physicochemical Methods
  • Biological Methods

Native, Modification, Mimesis

Structure--Property--Function--Reaction;

Structure--Property—Activity--Relationship