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Medical Applications of Nanotechnology

Medical Applications of Nanotechnology. Luke and Matt Group 1. Outline. Background Applications Current Research Nanocrystals as fluorescent biological labels (UC Berkeley) Magnetic Nanoparticles (NanoBMI) Tissue Engineering (University of Minnesota)

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Medical Applications of Nanotechnology

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  1. Medical Applications of Nanotechnology Luke and Matt Group 1

  2. Outline • Background • Applications • Current Research • Nanocrystals as fluorescent biological labels (UC Berkeley) • Magnetic Nanoparticles (NanoBMI) • Tissue Engineering (University of Minnesota) • DNA Chips (U. of Wisconsin, Stanford) • Detection of chemical and biological warfare agents (Naval Research Laboratory) • BioCom Chip (UC Berkeley) • Future Possibilites • Oxygen Selective Pump (Merkle) • Nanorobots, Respirocytes (Freitas, http://www.foresight.org/Nanomedicine) • Cell Repair Machines (Drexler) • Conclusion

  3. Background • Nanomedicine is the monitoring, repair, construction, and control of human biological systems at the molecular level using engineered nanodevices and nanostructures. • Microscopic machines were first hypothesized by Richard Feynman in 1959. • K. Eric Drexler described many applications of these machines in Engines of Creation. • Currently, several university and industrial research groups are developing medical applications for nanotechnology.

  4. Nanocrystals as Fluorescent Biological Labels 3.5 nm crystals bound to cell nucleus Bruchez, M. Jr., M. Moronne, P. Gin, S. Weiss, and A.P. Alivisatos. 1998. Semiconductor nanocrystals as fluorescent biological labels. Science 281:2013-2016. Chan, W.C.W., and S.M. Nie. 1998. Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281:2016-2018. http://www.wtec.org/loyola/nano/IWGN.Research.Directions/chapter08.pdf

  5. NanoBMI Biofunctional devices based on magnetic nanoparticles • Delivery and controlled release of therapeutics • Bioswitches for organ function • Imaging Charles Seeney President of NanoBMI http://www.nanobmi.com

  6. Tissue Engineering • Nano/micro particles, including living animal cells, bacteria, and colloidal gold (100 nm), can be optically guided and deposited in arbitrarily defined three-dimensional arrays, a process called “laser-guided direct-writing.” Odde, D.J. and M.J. Renn. 1998. Laser-based direct-write lithography of cells. Ann. Biomed. Eng. 26:S-141. http://www.wtec.org/loyola/nano/IWGN.Research.Directions/chapter08.pdf

  7. DNA Chips Yeast cells were grown under various conditions; the amount of red or yellow light represents the level of RNA produced from the DNA in that gene, under those conditions. Brown, P. 1999. http://cmgm.stanford.edu/pbrown/yeastchip.html http://www.wtec.org/loyola/nano/IWGN.Research.Directions/chapter08.pdf

  8. Detection of Chemical and Biological Warfare Agents One technique uses atomic force microscopy with a sandwich immunoassay attaching magnetic beads to a microfabricated cantilever sensitive to small displacements. J. Murday, Colton, R. 1999. (Chemistry Division, Naval Research Laboratory). http://www.wtec.org/loyola/nano/IWGN.Research.Directions/chapter08.pdf

  9. BioCOM Chip • Three cantilevers coated with three different antibodies, are exposed to prostate-specific antigen (PSA) • The left cantilever bends as PSA binds to the anti-PSA antibody on the cantilever • The other cantilevers do not bend because their antibodies do not bind to PSA. Min Yue, Katherine Dunphy, Henry Lin, Srinath Satyanarayana (http://www.nano.me.berkeley.edu/)

  10. Future Possiblities: Oxygen Selective Pump http://www.foresight.org/Nanomedicine/

  11. Respirocytes: A Mechanical Artifical Red Blood Cell • Bloodborne spherical 1-micron diamondoid 1000-atm pressure vessel • Active pumping powered by endogenous serum glucose • Able to deliver 236 times more oxygen to the tissues per unit volume than natural red cells and to manage carbonic acidity http://www.foresight.org/Nanomedicine/Respirocytes.html

  12. Fixing Damaged Blood Cells http://bionano.rutgers.edu/mru.html

  13. Conclusion • Currently, a variety of research is being performed on nanomedical devices. • Few industrial products exist right now. • The possibilities are endless, but will take time to develop.

  14. Sources • http://www.foresight.org/Nanomedicine/ • http://news-info.wustl.edu/tips/page/normal/203.html • http://wtec.org/loyola/nano/IWGN.Research.Directions/ • http://www.foresight.org/EOC/ • http://www.nanobmi.com/ • http://www.nano.me.berkeley.edu/ • http://bionano.rutgers.edu/mru.html

  15. In the Near Future: Humanoid Shaped Nanorobots!

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