Calcific Uremic Arteriolopathy. ‘Calciphylaxis’. David Shure. Calciphylaxis Syndrome. ‘Coined by Hans Selye ‘62 Nephrectomized rat model 1) Systemic Sensitization induced by agents i.e. PTH, vitamin D, or high Ca, P diet
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1) Systemic Sensitization induced by agents i.e. PTH, vitamin D, or high Ca, P diet
2) After ‘critical period’, exposure to appropriate challengers via SC injections of iron salt, egg albumin, polymyxin, glucocorticoids, causing local trauma, led to macroscopic visible deposits of calcium salts systemically and at site of injection
Serum calcium 8.4, albumin 3.6
Po4 5.5, iPTH 119, INR 2.0Skin Lesion Progression