Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream)

1. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) © The Swiss Pharmacy

2. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Kz Cream (Generic Ketoconazole 2% Cream) is used for the topical treatment of tinea corporis, tinea cruris and tinea pedis caused by Trichophyton rubrum, T. mentagrophytes and Epidermophyton floccosum. It is also used in the treatment of tinea (pityriasis) versicolor caused by Malassezia furfur (Pityrosporum orbiculare), in the treatment of cutaneous candidiasis caused by Candida spp. and in the treatment of seborrheic dermatitis. © The Swiss Pharmacy

3. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) KZ Cream is manufactured by Hegde & Hegde Pharmaceutica LLP, India. © The Swiss Pharmacy

4. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Chemical Structure © The Swiss Pharmacy

5. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) The active ingredient contained in KZ Cream is Ketoconazole 2%. Each gram of KZ Cream, for topical administration, contains Ketoconazole 20 mg and is formulated in an aqueous cream vehicle. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

6. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Uses of Kz 2% Cream: Kz cream contains a medicine called Ketoconazole. This belongs to a group of medicines called ‘antifungals’. Kz cream is used for fungal and yeast infections of the skinin adults. Infections may appear on the: Trunk, chest or back,Hands or feet,Scalp or face, Groin or genitals. Kz cream works by killing the fungus that causes the infection. Ketoconazole cream, 2% is indicated for the topical treatment of tinea corporis, tinea cruris and tineapedis caused by Trichophyton rubrum, T. mentagrophytes and Epidermophyton floccosum; in the treatmentof tinea (pityriasis) versicolor caused by Malassezia furfur (Pityrosporum orbiculare); in the treatment ofcutaneous candidiasis caused by Candida spp. and in the treatment of seborrheic dermatitis. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

7. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Recommended Adult Dosage The dose of Kz Cream Kz Cream (Generic Ketoconazole 2% Cream) is given below: Cutaneous Candidiasis, Tinea Corporis, Tinea Cruris, Tinea Pedis, And Cutaneous Candidiasis, Tinea Corporis, Tinea Cruris, Tinea Pedis, And Tinea (Pityriasis) Versicolor: Tinea (Pityriasis) Versicolor: It is recommended that Ketoconazole cream, 2% be applied once daily to cover the affected and immediate surrounding area. Clinical improvement may be seen fairly soon after treatment is begun. However, candidal infections and tinea cruris and corporis should be treated for two weeks in order to reduce the possibility of recurrence. Patients with tinea versicolor usually require two weeks of treatment. Patients with tinea pedis require six weeks of treatment. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

8. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Recommended Adult Dosage If a patient shows no clinical improvement after the treatment period, the diagnosis should be redetermined. Seborrheic Dermatitis: Seborrheic Dermatitis: Kz Cream (Generic Ketoconazole 2% Cream) should be applied to the affected areas once or twice daily. The usual initial duration of treatment in seborrheic dermatitis is 2 to 4 weeks. Maintenance therapy can be applied intermittently (once weekly) in seborrheic dermatitis. Treatment should be continued until a few days after the disappearance of all symptoms. The diagnosis should be reconsidered if no clinical improvement is noted after 4 weeks of treatment. General measures in regard to hygiene should be observed to control sources of infection or reinfection. Seborrhoeic dermatitis is a chronic condition and relapse is highly likely. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

9. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Kz Cream (Generic Ketoconazole 2% Cream) - How To Use Apply enough cream to cover the affected and surrounding skin areas, and rub in gently. To help clear up your infection completely, it is very important that you keep using the cream for the full time of treatment, even if your symptoms begin to clear up after a few days. Since fungus or yeast infections may be very slow to clear up, you may have to continue using this medicine every day for up to several weeks. If you stop using this medicine too soon, your symptoms may return. Do not miss any doses. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

10. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Contraindications ➔Kz Cream is contraindicated in patients with a known hypersensitivity to Ketoconazole or any component of the cream. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

11. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Storage Instructions Kz Cream (Generic Ketoconazole 2% Cream) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

12. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Warnings Ketoconazole cream, 2% is not for ophthalmic use. If a reaction suggesting sensitivity or chemical irritation should occur, use of the medication should be discontinued. Hepatitis (1:10,000 reported incidence) and, at high doses, lowered testosterone and ACTH induced corticosteroid serum levels have been seen with orally administered Ketoconazole. These effects have not been seen with topical Ketoconazole. A long-term feeding study in Swiss Albino mice and in Wistar rats showed no evidence of oncogenic activity. The dominant lethal mutation test in male and female mice revealed that single oral doses of Ketoconazole as high as 80 mg/kg produced no mutation in any stage of germ cell development. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

13. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Warnings If coadministered with a topical corticosteroid, to prevent a rebound effect after stopping a prolonged treatment with topical corticosteroids it is recommended to continue applying a mild topical corticosteroid in the morning and to apply Ketoconazole 2% cream in the evening, and to subsequently and gradually withdraw the topical corticosteroid therapy over a period of 2 to 3 weeks. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

14. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Possible Side Effects During clinical trials 45 (5.0%) of 905 patients treated with Ketoconazole cream (Kz Cream), 2% and 5 (2.4%) of 208 patients treated with placebo reported side effects consisting mainly of severe irritation, pruritus and stinging. One of the patients treated with Ketoconazole cream developed a painful allergic reaction. In worldwide postmarketing experience, rare reports of contact dermatitis have been associated with Ketoconazole cream or one of its excipients, namely propylene glycol. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

15. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Possible Side Effects Side effects identified during post approval use with Ketoconazole 2% Cream include burning sensation, pain, skin irritation, and erythema. Because these events are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

16. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Kz Cream Overdosage Excessive topical application of Kz Cream (Generic Ketoconazole 2% Cream) may lead to erythema, oedema and a burning sensation, which will disappear upon discontinuation of the treatment. In the event of accidental ingestion of the cream, supportive and symptomatic measures should be carried out. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

17. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Ketoconazole 2% Cream During Pregnancy Ketoconazole 2% Cream (Kz Cream) has been classified by the US FDA as Pregnancy Category C. Ketoconazole has been shown to be teratogenic (syndactylia and oligodactylia) in the rat when given orally in the diet at 80 mg/kg/day, (10 times the maximum recommended human oral dose). However, these effects may be related to maternal toxicity, which was seen at this and higher dose levels. There are no adequate and well-controlled studies in pregnant women. Ketoconazole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

18. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Ketoconazole 2% Cream During Nursing It is not known whether Ketoconazole is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Ketoconazole cream (Kz cream) is administered to a nursing woman. A decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. If used during lactation and Kz Cream is applied to the chest, care should be taken to avoid accidental ingestion by the infant. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy

19. Kz Cream by Hegde and Hegde (Generic Ketoconazole 2% Cream) Kz Cream Kz Cream (Generic Ketoconazole 2% Cream) is manufactured by Hegde and Hegde Pharmaceutica LLP, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html https://www.theswisspharmacy.com/product_info.php?info=p9582_Ketoconazole-Cream.html © The Swiss Pharmacy