Forcan Tablets (Generic Fluconazole Tablets)

1. Forcan Tablets (Generic Fluconazole Tablets) © The Swiss Pharmacy

2. Forcan Tablets (Generic Fluconazole Tablets) Forcan (Generic Fluconazole Tablets) is used to treat certain types of fungal or yeast infections. Forcan tablets are used for the treatment of the following Systemic candidiasis, Mucosal candidiasis, Cryptococosis and prevention of fungal infection in patients with malignancy. © The Swiss Pharmacy

3. Forcan Tablets (Generic Fluconazole Tablets) Forcan Tablets are manufactured by Cipla Limited, India in the strengths of 50 mg, 150 mg and 200 mg. © The Swiss Pharmacy

4. Forcan Tablets (Generic Fluconazole Tablets) Chemical Structure © The Swiss Pharmacy

5. Forcan Tablets (Generic Fluconazole Tablets) The active ingredient contained in tablets is Forcan tablets is Fluconazole. Each uncoated Forcan tablet contains 50 mg, 150 mg or 200 mg of Fluconazole respctively. © The Swiss Pharmacy

6. Forcan Tablets (Generic Fluconazole Tablets) Uses of Forcan 50 mg, 150 mg and 200 mg tablets: Forcan (Generic Fluconazole Tablets) is used to treat serious fungal or yeast infections, including vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of the stomach], and infections that may occur in different parts of the body), or fungal (cryptococcal) meningitis. This medicine works by killing the fungus or yeast, or preventing its growth. Fluconazole is also used to prevent candidiasis in patients having bone marrow transplants who receive cancer or radiation treatment. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

7. Forcan Tablets (Generic Fluconazole Tablets) Recommended Adult Dosage The dose of Forcan tablets Forcan tablets (Generic Fluconazole tablets) to treat Systemic Candida Infections in adults is 400 mg initially, followed by 200 to 400 mg once daily. Treatment duration is based on clinical and mycological response, but is usually at least 6 to 8 weeks in cryptococcal meningitis. To prevent relapse after a primary course of treatment for acute cryptococcal meningitis in AIDS patients: 100 to 200 mg daily. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

8. Forcan Tablets (Generic Fluconazole Tablets) Recommended Adult Dosage The initial dose to treat Mucosal Candidiasis in adults is 50 mg daily, which may be increased to 100 mg daily if needed. The treatment duration is 7 to 14 days (oropharyngeal candidiasis, except in severely immunocompromised patients), 14 days (atrophic oral candidiasis associated w/ dentures), 14 to 30 days (other mucosal candidiasis including oesophagitis). The initial dose to treat Cryptococcal Infections in adults is 400 mg, followed by 200 to 400 mg once daily. Treatment duration is based on clinical and mycological response, but is usually at least 6- to 8 weeks in cryptococcal meningitis. To prevent relapse after a primary course of treatment for acute cryptococcal meningitis in AIDS patients: 100 to 200 mg daily. © The Swiss Pharmacy

9. Forcan Tablets (Generic Fluconazole Tablets) Recommended Adult Dosage For the Prophylaxis of Fungal Infections in Immunocompromised adult patients the dosage is 50 to 400 mg daily. The recommended Fluconazole daily dosage for the prevention of candidiasis in patients undergoing bone marrow transplantation is 400 mg, once daily. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

10. Forcan Tablets (Generic Fluconazole Tablets) Contraindications ➔Forcan tablets are contraindicated in patients with a known hypersensitivity to Fluconazole or any component of the tablet. ➔There is no information regarding cross-hypersensitivity between Forcan Tablets and other azole antifungal agents. ➔Caution should be used in prescribing Forcan Tablets to patients with hypersensitivity to other azoles. ➔Co-administration of Terfenadine is contraindicated in patients receiving Forcan Tablets at multiple doses of 400 mg or higher based upon results of a multiple-dose interaction study. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

11. Forcan Tablets (Generic Fluconazole Tablets) Contraindications ➔Co-administration of other drugs known to prolong the QT interval and that are metabolised via the enzyme CYP3A4, such as Cisapride, Astemizole, Pimozide and Quinidine, are contraindicated in patients being administered Fluconazole tablets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

12. Forcan Tablets (Generic Fluconazole Tablets) Storage Instructions Forcan Tablets (Generic Fluconazole Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

13. Forcan Tablets (Generic Fluconazole Tablets) Warnings Fluconazole should be administered with caution to patients with liver dysfunction. Fluconazole has been associated with rare cases of serious hepatic toxicity, including fatalities primarily in patients with serious underlying medical conditions. In cases of Fluconazole- associated hepatotoxicity, no obvious relationship to total daily dose, duration of therapy, sex, or age of the patient has been observed. In rare cases, anaphylaxis has been reported. Exfoliative skin disorders during treatment with Fluconazole have been reported. Fatal outcomes have been reported in patients with serious underlying diseases. Patients with deep seated fungal infections who develop rashes during treatment with fluconazole should be monitored closely and the drug discontinued if lesions progress. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

14. Forcan Tablets (Generic Fluconazole Tablets) Warnings Fluconazole should be discontinued in patients treated for superficial fungal infection who develop a rash that may be attributed to Fluconazole. Case reports describe a pattern of distinct congenital anomalies in infants exposed in utero to high dose maternal fluconazole (400 to 800 mg/day) during most or all of the first trimester. Forcan tablets should be administered with caution to patients with renal dysfunction. Adrenal insufficiency has been reported in patients receiving azoles, including Fluconazole. Reversible cases of adrenal insufficiency have been reported in patients receiving Fluconazole. Patients on long-term treatment with Forcan tablets and Prednisone should be carefully monitored for adrenal cortex insufficiency when fluconazole is discontinued. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

15. Forcan Tablets (Generic Fluconazole Tablets) Driving and Operating Machinery When driving vehicles or operating machines it should be taken into account that occasionally dizziness or seizures may occur. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

16. Forcan Tablets (Generic Fluconazole Tablets) Possible Side Effects Most common Forcan side effects with an incidence rate of greater than 10% are headache, abdominal pain, diarrhoea, nausea, vomiting, alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased and rash. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

17. Forcan Tablets (Generic Fluconazole Tablets) Possible Side Effects The following side effects occurred in greater than 1/1000 to less than 1/100 of patients and include Anaemia, Decreased appetite, Somnolence, insomnia, Seizures, paraesthesia, dizziness, taste perversion, Vertigo, Constipation, dyspepsia, flatulence, dry mouth, Cholestasis, jaundice, bilirubin increased, Drug eruption, urticaria, pruritus, increased sweating, Myalgia, Fatigue, malaise, asthenia and fever. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

18. Forcan Tablets (Generic Fluconazole Tablets) Overdosage There have been reports of overdose with Fluconazole accompanied by hallucination and paranoid behaviour. In the event of Forcan overdose, symptomatic treatment (with supportive measures and gastric lavage if clinically indicated) should be instituted. Fluconazole is largely excreted in urine; forced volume diuresis would probably increase the elimination rate. A 3-hour haemodialysis session decreases plasma levels by approximately 50%. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

19. Forcan Tablets (Generic Fluconazole Tablets) Forcan Tablets During Pregnancy Fluconazole (Forcan Tablets) has been classified by the US FDA as Pregnancy Category C for single 150 mg tablet use for Vaginal Candidiasis and Pregnancy Category D for all other indications. There are no adequate and well-controlled clinical trials of Fluconazole in pregnant women. A few published case reports describe a rare pattern of distinct congenital anomalies in infants exposed in-utero to high dose maternal Fluconazole (400 to 800 mg/day) during most or all of the first trimester. These reported anomalies are similar to those seen in animal studies. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

20. Forcan Tablets (Generic Fluconazole Tablets) Forcan Tablets During Pregnancy Use in pregnancy should be avoided except in patients with severe or potentially life-threatening fungal infections in whom Fluconazole may be used if the anticipated benefit outweighs the possible risk to the foetus. In case this medicine is used during pregnancy, or if the patient becomes pregnant while taking the medication, the patient should be informed of the potential hazard to the fetus. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy

21. Forcan Tablets (Generic Fluconazole Tablets) Forcan Tablets Forcan Tablets (Generic Fluconazole Tablets) are manufactured by Cipla Limited, India. URL: URL: https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html https://www.theswisspharmacy.com/product_info.php?info=p9541_Fluconazole-Tablets.html © The Swiss Pharmacy