Diagnostic View of IVF Success Rates
SUCCESS RATES INS AND OUT • Have you chosen the best IVF center in India • What to look for? • How to diagnose the IVF success ratio • What are global facts about IVF success? • What does Success really means? • How IVF success can be measures? • How you can evaluate the success of IVF center? • How to combine Outcome for Rational Decision ?
HAVE YOU CHOSEN THE BEST IVF CENTER?
WHAT TO LOOK FOR? IVF cost? Patient care? Best IVF doctor?
The most important factor is to look for “what is the success ratio of center for IVF treatment?”
How to diagnose the IVF success rates of center? What are global IVF success rates? Understand what actually success rates mean? How to calculate the success without Advanced degree in statistics?
SOME GLOBAL FACTS AND FIGURES ABOUT IVF • More than 165,172 IVF procedures were performed in 2015 • 61,740 babies were born • 5% chances of getting pregnant for women more than 40 each month • 25% of IVF births resulted in twins • Less than 1 % number of triplets, quads, and quintuplet births from IVF • 25.6% women get pregnant with IVF in 2010 • 52.9% ICSI procedures and 47.1% IVF procedures were performed
WHAT DOES IVF SUCCESS RATES MEAN?
UNDERSTAND THE SUCCESS RATES WITH THE ONGOING IVF CYCLE • Initialization of IVF cycle • IVF cycle get start with the ovulation stimulation with the induced drugs and the hormones induction. • Sofat Infertility Center initiated the IVF cycle With 5000 IVF cases in year 2015
CANCELLATION • Out of 5000 women some give poor • response to the medication of ovulation • stimulation
REASON FOR CANCELLATION • Age can be biggest factor for cancellation of IVF cycle before egg retrieval • 10% cases were cancelled before egg retrieval
EGG RETERIVAL • It is the step in which egg are obtained from the ovarian follicles for initiating the fertilization process • Out of 5000 cases only 4500 performed the egg retrieval
EGG FERTILIZATION • Next step of ladder of IVF success is the successful fertilization of egg by mixing it with the male sperm. It is observed for 3-4 days until it turns into cell balls called embryo • Semen sample is taken from male partner
In Case Of Male Infertility Issues Like Low Sperm Count ICSI Procedure Is Performed To Fertilize The Egg
CANCELLATION • After keeping egg in the cultured lab IVF cycle can get canceled • Out of 4500 only 3900 IVF cycle proceeded with the next step
REASONS FOR DISCREPANCY • Embryo is not developed up to the point of transfer as IVF specialist want the highest quality embryo • Genetic testing of embryo has revealed it as abnormal • if a woman’s progesterone levels is high before transfer as otherwise it can lead to miscarriage
EMBRYO TRANSFER • Next crucial step is embryo implantation. In this highest quality embryo is placed back in the uterus of women. • 78% women of the total women initiated cycle, get embryo transfer
CLINICAL PREGNANCY? • It refers to the positive results of the pregnancy test after the pregnancy test
FACTS OF CLINICAL PREGNANCY • About 55% women get pregnant after first IVF cycle • More than 3000 women get pregnant after first IVF cycle
REASONS FOR FAILED IVF CYCLE • Age is the biggest factor that can lower down the success rates • Failure can be due to some genetic reasons • Frozen or older eggs have insufficient spindle apparatus so lead to abnormal embryo development
VARIATION IN IVF SUCCESS RATES • Success rates for IVF start decreasing after the age of 35 • With the age higher risk of miscarriage • Success rates can be higher if old age women get donor eggs of women of age 20 -30 • Success rates can vary on the basis of number of embryo transferred
CALCULATION OF IVF SUCCESS RATES • ask the ratio of successful IVF cycles according to age • ask the success of treatment with the comparative view to number of embryo transfer • ask for the success of IVF with ICSI, blastocyst , laser hatching Frozen embryo, Frozen eggs, Donor Sperms and Fresh Egg
HOW TO EVALUATE THE CENTER’S SUCCESS FOR IVF? Success Rates Can Vary Between Individuals And The Characteristics Of The Individuals Lead To Variation In IVF Programs
EVALUATE THE COMBINATION OF OUTCOMES • live birth rate per initiated cycle • implantation rate • rate of multiple pregnancies • average number of embryo transferred • number of cycles performed for successful pregnancy
TAKE THE RATIONAL DECISION Understand the reasons for failure for IVF cycle and its relative success and if the ratio of success per cycle is higher then choose the center as your guide for future of your family