Cough Guidelines The European Perspective. Alyn Morice University of Hull. Points of difference. The majority of the guidelines from both ERS, BTS and ACCP are consistent and agreed. However there are some areas of disagreement. Evidenced based vs opinion based.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Cough Guidelines The European Perspective Alyn Morice University of Hull
Points of difference The majority of the guidelines from both ERS, BTS and ACCP are consistent and agreed. However there are some areas of disagreement. • Evidenced based vs opinion based
Trials of over 1000pts in NEJM, Lancet, Annals, JAMA Compared with preceding meta analysis 12 trials, 19 meta-analyses, 40 endpoints Only 67% agreement Meta analysis did not predict the result of the RCT in 35% of cases Discrepancies between meta-analyses and subsequent large randomized, controlled trials LeLorier J NEJM 1997 337 536-542
Points of difference • Evidenced based vs opinion based • Defined diagnosis vs symptom complex
Definitions The chief merit of language is clearness, and we know that nothing detracts from this so much as unfamiliar terms Galen
The problems of definition in cough diagnosis • The asthma syndromes • PNDS/UACS • GERD/GORD
No correlation of diagnosis with:- • Histology • (Irwin RS 2006; 130 362-370) • Inflammatory markers in induced sputum • (Chaudri R J Allergy Clin Immunol 2004; 113 1063-1070, Birring S Am L Respir Crit Care Med 2004; 169 15-19) • Neuropeptides (sputum and serum) • (Chaudri R Clin Exp Allergy 2005; 35 949-953)
The chronic cough survey • A cross-sectional survey in Leeds and Bradford • Recruitment via 36 general practices • Subjects aged 40 - 49 years • Randomly selected from the practice computer databases • Questionnaires sent to 6,416 • 4,003 (62%) responded • 3,883 (97%) completed the cough questions
The chronic cough survey • Asked how often in the last two months they had experienced bouts or spasms of coughing • Responses on a five-point Likert scale: • not at all; less than once a month; between once a month and once a week; between once a week and once a day; and once a day or more. • cough frequency was dichotomised using a cut-off point of once a week and once a day and above • Cough severity treated similarly
Overall prevalence of chronic cough 12% severity 7% Ford AC, Forman D, Moayyedi P, Morice AH. Cough in the community: a cross sectional survey and the relationship to gastrointestinal symptoms. Thorax 2006;61:975-9.
Points of difference • Evidenced based vs opinion based • Defined diagnosis vs symptom complex • History unhelpful vs history diagnostic
The diagnosis of reflux cough • Virtually all reflux is due to transient opening of the lower oesophageal sphincter Mittal NEJM 1997
Hull Cough Clinic REFLUX COUGH QUESTIONNAIRE
Symptoms in reflux cough study • Hull Cough Clinic between January 2002 and March 2004 • All new patients probability-based management algorithm • Semi-structured history • In those with gastroesophageal disease shown on oesophageal • manometry and/or 24 hour oesophageal pH monitoring • Case notes reviewed. • Presenting symptoms were collated to determine • the characteristic history of GOR-related cough. Everett Resp Med 2006
Points of difference • Evidenced based vs opinion based • Defined diagnosis vs symptom complex • History unhelpful vs history diagnostic • Different investigational strategy
Larynx in reflux cough Arytenoid erythema Posterior commisure hypertrophy Vocal fold oedema Ventricular obliteration
Cough counts on two days in the same individual as recorded by HACC
Points of difference • Evidenced based vs opinion based • Defined diagnosis vs symptom complex • History unhelpful vs history diagnostic • Different investigational strategy • Different interpretation of the therapeutic response
Can some “antihistamines” affect the VR1 cough receptor
Disofrol current experience 76 patients with intractable cough 68 female Reflux 52% Unknown 23% Cystic fibrosis 8% Asthma 4%
Results of Diary Data in chronic cough N=27 • Mean Cough scores • Placebo: 4.97 (1.68) • MST : 3.44 (1.75) • P value : <0.0001 Morice AH et al 2006 AJRCCM