Cannabinoids for Fibromyalgia Pain - Pure Form Global

1. Cannabinoids for Fibromyalgia Pain By Pure Form Global https://pureformglobal.com/

2. What is Cannabinoids for Fibromyalgia Pain? • Fibromyalgia is a poorly understood syndrome, characterized by chronic widespread pain, fatigue, and sleep disturbance. It appears to involve an alteration of central pain pathways, in which mast cells, which mediate activation of microglia through cytokines like interleukin 1 beta (IL-1B), interleukin 6 (IL-6), and tumor necrosis factor (TNF) alpha, play a central role. It may as well overlap with other conditions. Existing treatments, none of them completely satisfactory, include memantine, naltrexone, tapentadol, duloxetine, and palmitoylethanolamide. https://pureformglobal.com/

3. Cannabinoids for Fibromyalgia Pain? • Cannabinoids may be of promise. This is because they generally show anti-inflammatory and immunomodulatory activity, and often possess a demonstrated analgesic capability, acting on cannabinoid receptors and ihibiting presynaptic gamma-aminobutyric acid (GABA) and glutamatergic transmission. For reasons not completely known, activation of receptors CB1 and CB2 in general seems to have anti-pain-perception effects overall. The exact nature of fibromyalgia pain is elusive, however, since it appears not to be a function of any apparent tissue damage. https://pureformglobal.com/

4. Fibromyalgia Pain • On available research evidence, the likeliest cannabinoids to be of help are tetrahydrocannabinol (THC) and cannabidiol (CBD). Both act on CB1 and CB2 receptors. The former influences pain, appetite, orientation, and mood; the latter has anti-inflammatory, anti-anxiety, and analgesic effects. THC is a partial agonist; CBD is primarily a negative allosteric modulator of CB1. This, and the likely existence of an entourage effect, suggests that in combined therapy the proportion of THC to CBD would be of central importance in the development of cannabinoid-based therapy. https://pureformglobal.com/

5. Fibromyalgia Pain • Studies confirm that this balance matters, and have shown that there is indeed some symptomatic relief to be had with nabilone and dronabinol (a synthetic form of THC) in neuropathic pain at least, though adverse effects are not unknown. Studies on the direct use of cannabinoids in fibromyalgia, which does not appear classically neuropathic, do exist as well. They center on nabilone, dronabinol, Bedrocan (22.4 mg THC, <1 mg CBD), Bediol (13.4 mg THC, 17.8 mg CBD), and Bedrolite (18.4 mg CBD, <1 mg THC). https://pureformglobal.com/

6. Conclusion • PureForm CBD™ is bioidentical to CBD extracted from hemp and cannabis but without residual cannabinoids like THC or any of the impurities or chemicals associated with plant-derived production processes. Our molecular assembly technique, that synthesizes CBD from aromatic terpenes instead of cannabis, assures you the food and pharmaceutical-grade quality that you need for quality-conscious customers. If you are interested in PureForm CBD™ or want to partner on any other of the 140+ known cannabinoids. https://pureformglobal.com/

7. Thanks! You can find me at: @username: Damian Peters Mail Us : info@pureformglobal.com Contact Us : 310-666-486988 Visit Us : https://pureformglobal.com/ https://pureformglobal.com/