Gastroesophageal Reflux Disease. Scott Stolte, Pharm.D. Shenandoah University. Overview of GERD. Definition Symptoms or mucosal damage produced by the abnormal reflux of gastric contents into the esophagus Classic symptom is frequent and persistent heartburn
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Scott Stolte, Pharm.D.
If present, consider an endoscopy:
Esophageal mucosal resistance: Alginic acid, Sucralfate
Esophageal clearance: Cisapride
LES pressure: MetoclopramideCisapride
Gastric emptying: Metoclopramide Cisapride
Gastric acid: Antacids H2RAs PPIs
Antacids with or without alginic acid
1) Severity of disease
2) Duration of therapy
3) Dosage regimen used
Proton Pump Inhibitors
Prokinetic Agents -- MOA