Simvastatin Increases HDL-C and Apolipoprotein A-1 Levels Significantly More Than Atorvastatin Preloader

Simvastatin Increases HDL-C and Apolipoprotein A-1 Levels Significantly More Than Atorvastatin - PowerPoint PPT Presentation


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Simvastatin/Atorvastatin HDL Study Background. HDL-C and apolipoprotein (apo) A-1 levels are inversely related to the risk of coronary heart disease.Recently the VA-HIT study suggested that modest increases in HDL-C could have significant benefits on cardiovascular events. Statins, in addition to lowering LDL-C and TG, increase HDL-C levels.However, recent data suggest that a differential effect of simvastatin and atorvastatin on HDL-C exists, in that at higher doses of both drugs simvastati9452

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