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Angina. Clinical syndrome characterize by episodes of chest discomfort (pain) or pressureTypically caused by an imbalance in myocardial oxygen supply versus myocardial oxygen demand.>6 million people in US have angina.. Etiology. Typically caused by atherosclerotic heart disease in combination with increased oxygen demand.Unstable angina is also thought to be associated with a temporary blood clot (plaque rupture and bleed) superimposed on atherosclerotic plaque..

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