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Robert Koch. Linking Bacteria to Human Disease. Order of Progress. Prevention Cause Cure. Biography. A doctor who was Born in Prussia in 1843 Interested in Pasteur’s Germ Theory He received a Microscope as a present in 1873 Franco – Prussian Rivalry Franco-Prussian War 1870/1

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robert koch

Robert Koch

Linking Bacteria to Human Disease

order of progress
Order of Progress
  • Prevention
  • Cause
  • Cure
biography
Biography
  • A doctor who was Born in Prussia in 1843
  • Interested in Pasteur’s Germ Theory
  • He received a Microscope as a present in 1873
  • Franco – Prussian Rivalry
    • Franco-Prussian War 1870/1
    • German Government gave Koch money to set up a research institute to rival Pasteur

Read Dialogue page 130

isolating the germs that caused anthrax
Isolating the Germs that caused Anthrax
  • Explain how 1 Sheep and 20 generations of mice allowed Koch to prove that a particular germ caused Anthrax. Explain why he succeeded?
germ cultures
Germ Cultures
  • Koch’s isolation technique pioneered the use of culture plates
    • He extracted the blood from an infected animal
    • He found that if he injected an animal with the infected blood it would catch the disease much quicker
    • The more times he did this the stronger the disease would become
    • Eventually, this germ could be extracted and be encouraged to breed a pure form in a glass culture plate.
the floodgates open
The Floodgates open
  • Using Koch’s methods, other scientists were able to isolate and identify the germs that caused particular diseases
  • List the causes of diseases discovered in the 1880s and 1890s
    • Page 131
  • However, knowing the cause of these diseases still did not help to treat any sick patients, yet.
pasteur strikes back
Pasteur Strikes back
  • Prevention
  • Cause
  • Cure
pasteur responds to robert koch
Pasteur responds to Robert Koch
  • Nationalistic Competition
    • France humiliated by Prussia in 1870/1 war
  • French Government agrees to finance Pasteur
    • (Koch already receiving German Government money)
  • He had a stroke in 1868
    • Feeling mortal?
pasteur strikes it lucky
Pasteur Strikes it Lucky
  • Impressed by Jenner’s work on Smallpox
    • But Jenner and Pasteur did not understand how vaccination worked
    • Trial and error
  • Chicken Cholera, 1879
    • Common disease affecting farmers livestock
    • Pasteur experiments with injecting weaker forms of disease into chickens
      • Little success
      • His team goes home for the summer
      • On return, they accidentally use a strain that had been left uncovered for the whole summer
      • It works!
      • Exposure to the air had weakened the germs
  • “Chance only favours the mind which is prepared”
pasteur perfects his system
Pasteur perfects his system
  • Page 132
    • Explain how and for what diseases, Pasteur was able to develop and perfect his system for creating vaccines.
  • Task page 133
    • “Why were the causes of disease finally discovered in the 1860s and 1870s”