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Is Terbium-161 Given in Cycles

This PPT explains the cyclic dosing approach of Tb-161 therapy, typically delivered in up to six cycles spaced at six-week intervals. It emphasizes how cyclic dosing improves tumor control, enables response monitoring, and leverages advanced dosimetry for safe, adaptive treatment.

Nuclearmedicinetherapy
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Is Terbium-161 Given in Cycles

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  1. Nuclear Medicine Centre FMRi Gurugram INDIA Dr. Ishita B Sen Is Terbium-161 Given in Cycles? www.nuclearmedicinetherapy.in

  2. Overview of Tb-161 Therapy • Used in treating metastatic castration-resistant prostate cancer (mCRPC) • Administered as [161Tb]Tb-PSMA-I&T • Delivered in multiple treatment cycles for better efficacy and safety

  3. Why Is Cyclic Dosing Important? • Typically up to six cycles, spaced 6 weeks apart • Repeated dosing targets micrometastatic disease • Sustains pressure on cancer cells to disrupt tumor growth • Helps improve long-term outcomes

  4. Monitoring After Each Cycle • Each cycle allows for: • Evaluating tumor response • Monitoring side effects • Adjusting future doses based on progress

  5. Role of Dosimetry in Treatment • SPECT/CT scans performed post each cycle • 3D voxel-based dosimetry calculates radiation absorbed • Enables personalized adjustments to protect organs like: • Kidneys • Salivary glands • Bone marrow

  6. Clinical Research Supports This Approach • VIOLET trial shows high tumor dose delivery with Tb-161 • Safe and effective with minimal added toxicity • Research confirms cyclic dosing improves therapeutic index

  7. Conclusion • Cyclic Tb-161 therapy is a strategic and science-backed approach • Provides precision, adaptability, and patient-specific safety • A promising option in advanced prostate cancer management Disclaimer: This information is intended for general knowledge and informational purposes only, and does not constitute medical advice. Please consult with a qualified healthcare professional for any medical concerns or treatment decisions.

  8. For more information talk to Dr. Ishita B Sen today. dr.ishitasen@nuclearmedicinetherapy.in +91 8700 668 431 www.nuclearmedicinetherapy.in

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