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Dosimetry in Terbium-161 Therapy

This PPT details how SPECT/CT-based dosimetry is performed after each cycle of Tb-161 therapy. It shows how clinicians use this data to customize and adjust doses, minimizing toxicity and improving treatment precision in prostate cancer care. Know more at https://nuclearmedicinetherapy.in/

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Dosimetry in Terbium-161 Therapy

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  1. Nuclear Medicine Centre FMRi Gurugram INDIA Dr. Ishita B Sen Dosimetry in Terbium-161 Therapy www.nuclearmedicinetherapy.in

  2. What is Dosimetry? • Dosimetry = Measuring the radiation dose absorbed by the body • Helps personalize treatment and reduce risk to healthy tissues • Especially important in radioligand therapies like Tb-161

  3. Why Dosimetry with Tb-161? • Tb-161 emits beta, Auger, and conversion electrons • Delivers 35–40% more energy per decay than Lu-177 • Also emits gamma rays, making post-therapy imaging feasible • Imaging enables accurate dose mapping via SPECT/CT

  4. VIOLET Trial & Imaging Protocol • Clinical trial: NCT05521412 • Post-therapy SPECT/CT scans done at: • ✅ 4 hours • ✅ 24 hours • ✅ 96 hours • Creates 3D patient-specific dose maps • Tracks radiation in tumors and at-risk organs: • Salivary glands • Kidneys • Bone marrow

  5. Personalized Treatment with Safety • Each cycle’s dosimetry guides next dose adjustment • Allows adaptive treatment planning • Reduces risks of toxicity while enhancing effectiveness

  6. Precision Over One-Size-Fits-All • Without dosimetry: risk of overdosing healthy tissue • With dosimetry: • Tailored dosing • Safer outcomes • Higher tumor control

  7. Key Takeaway • Dosimetry transforms Tb-161 into a customized therapy • Balances powerful tumor-targeting with real-time safety oversight • A major advantage over traditional radioligand treatments Disclaimer: This information is intended for general knowledge and informational purposes only, and does not constitute medical advice. Please consult with a qualified healthcare professional for any medical concerns or treatment decisions.

  8. For more information talk to Dr. Ishita B Sen today. dr.ishitasen@nuclearmedicinetherapy.in +91 8700 668 431 www.nuclearmedicinetherapy.in

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