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The Endothelial Glycocalyx is a network of membrane-bound proteoglycansand Glycoproteins, covering the Endothelium luminally. Both Endothelium-and plasma-derived soluble molecules integrate into this mesh.
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The Endothelial Glycocalyx Micro Vascular Health Solution
The Endothelial Glycocalyx is a network of membrane-bound proteoglycans and Glycoproteins, covering the Endothelium luminally. Both Endothelium- and plasma-derived soluble molecules integrate into this mesh. The Endothelial Glycocalyx was already visualized some 40 years ago by Luft using electron microscopy. Still, relatively little is known of the composition and function of this layer. Micro Vascular Health Solution
The vascular endothelium is the largest organ in the body, forming an interface between the bloodstream and the blood vessel wall It provides the building block needed for a strong and functional vascular endothelium. Over the last few years, the potential possible pathophysiological roles of eGCX have been the focus of intense research. Disruption or dysfunction of the eGCX has been associated with disease states such as diabetes, chronic kidney disease (CKD), inflammatory conditions, sepsis, hypernatraemia, hypervolaemia and ischaemia/reperfusion injury. Micro Vascular Health Solution
Glycocalyx is a highly charged layer of membrane-bound biological attached to a cell membrane. This layer functions as a barrier between a surrounding. macromolecules cell and its Micro Vascular Health Solution
Glycocalyx also serves as a mediator for cell-cell interactions and protects a cell membrane from the direct action of physical forces and stresses allowing the membrane to maintain its integrity. Glycocalyx is also involved in development and progression of many diseases. Glycocalyx is composed of glycosaminoglycans, proteoglycans and other glycoproteins bearing acidic oligosaccharides and terminal sialic acids. Micro Vascular Health Solution
Most proteins are transmembrane that can be linked to the cytoskeleton. This linkage not only restricts their position and constitutes the foundation of the glycocalyx structure, but it also allows signal transduction from the external to the internal parts of a cell. Here we focus on the endothelial cells' glycocalyx. glycocalyx associated Micro Vascular Health Solution
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