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Opportunities to Reduce Oral Health Disparities: Basic Sciences to Clinical Practice Peter Milgrom, DDS University of Southern California, February 2003. University of Washington Northwest/Alaska Center for Research to Reduce Oral Health Disparities.
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Opportunities to Reduce Oral Health Disparities: Basic Sciences to Clinical Practice
Peter Milgrom, DDS
University of Southern California, February 2003
The oral soft tissue and saliva make defenses against bacteria.
These defenses include beta-defensins,natural antibiotics.
We believe that these beta-defensins help to prevent dental caries.
Leonor de Maldonado, Principal, Toppenish Middle School
Susan Vlahakis, RN special education
Pat Brown, DSHS Children’s Program Manager and Yakima County Children’s Oral Health Coalition
James Falco, Dean, Arts & Sciences, Heritage College
Robert Ozuna, Director, UW-Yakima Valley Comm Partnerships, Heritage Center
Barbara Owens, Director Dental Admin. Services, YVFWC
Mark Koday, DDS, Dental Director, YVFWC
Cheryl Vyhmeister, Mobile Unit Coordinator, YVFWCMore People
Defensins are natural antibiotic peptides
- and we make them !!!
They are inherited like hair color and height.
Is there a difference in children with low and high dental decay?
Measure the amount of beta-defensins in saliva
Look at genetic differences
We chose Toppenish for our study because of the history of the University of Washington Dental School in promoting oral health in the Yakima Valley area, because of the location near Heritage College, a partner in education and research, and because of the YVFWC.
We have found single base pair changes in the genes for beta-defensins.
These changes, called single nucleotide polymorphisms (SNPs) are a very common type of genetic variation. SNPs can be silent, deleterious, or even advantageous.
Preliminary data shows a possible protective effect of one SNP (-44).
Caries 0 Lo Hi
Number 50 47 47
SNP -44 0.40 0.47 0.53
There is not an association of this hBD-1 SNP with caries experience. Our findings did not support the trend of the pilot data.
Be part of the Solution
OBJECTIVE To examine the usefulness of early orthodontic intervention as a means of increasing access to orthodontic services for children of low-income families
Develop community-based research that translates existing knowledge and new information about children and their caretakers into new technologies and interventions that will reduce disparities
Matched Private-Pay Patients