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Mechanical Ventilation. Biochemical Injury. Biophysical Injury. Distal Organs Affected MSOF Slutsky, Tremblay AJRCCM 1998;157:1721. . . . . . Hickling ICM 1990; 16:216. 50 ARDS patientsMortality: actual 16%, predicted 40%SIMV, volume targetedPIP < 40 cmH2OVT as low as 5 mL/kgPaCO2 averaged about 60 mmHgPEEP 9 6 cmH2O, FIO2 < 0.60.

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