Thrombocytopenia. Rahul Gladwin, MS3 University of Health Sciences-Antigua School of Medicine. Thrombocytopenia. Causes of Thrombocytopenia TTP/ITP Drug-induced Thrombocytopenia HIV-associated Thrombocytopenia Disseminated intravascular coagulation Pancytopenia Complications Management
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Rahul Gladwin, MS3
University of Health Sciences-Antigua
School of Medicine
1. Decreased production of platelets
2. Decreased platelet survival
A 21-year-old man with no significant PMH presents with complaints of hematuria and mucosal bleeding while brushing his teeth. The patient complains of intermittent "ringing in the ears." He denies any drug or alcohol use. He has no family history of bleeding disorders. Petechiae are noted in the oral cavity, as is dried blood in the nostrils.
Hematocrit 32% | WBC 8,000/mm3 with 60% neutrophils.
Platelet count 13,000; PT 13 seconds; PTT 28 seconds; LDH 1,200 U/L.
Elevated indirect bilirubin.
Coombs' test is positive; abdominal examination is normal.
Peripheral smear shows spherocytes.
A) Alport's syndromeB) Bernard-Soulier syndromeC) Felty's syndromeD) Thrombotic thrombocytopenic purpuraE) Evans' syndromeF) Idiopathic thrombocytopenic purpura (ITP)