Reactions of Alcohols. Oxidation R-X, Ether, and Ester Preparation Protection of Alcohols Synthesis The Logic of Mechanisms. Alcohols are Synthetically Versatile. Oxidation levels of oxygen- halogen- and nitrogen- containing molecules. Oxidation - Reduction.
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R-X, Ether, and Ester Preparation
Protection of Alcohols
The Logic of Mechanisms
Step 1: Protonation.
Step 2: Formation of the carbocation.
Step 3: Bromide attacks the carbocation.
When 3-methyl-2-butanol is treated with concentrated HBr, the major product is 2-bromo-2-methylbutane. Propose a mechanism for the formation of this product.
The alcohol is protonated by the strong acid. This protonated secondary alcohol loses water to form a secondary carbocation.
A hydride shift transforms the secondary carbocation into a more stable tertiary cation. Attack by bromide leads to the observed product.