Preclinical Animal Models of Cartilage Repair and Regeneration. Matthew J. Allen, Vet. M.B., Ph.D. Associate Professor, Orthopedic Surgery SUNY Upstate Medical University, Syracuse, New York. Overview. Why use animal models to study cartilage repair?
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Matthew J. Allen, Vet. M.B., Ph.D.
Associate Professor, Orthopedic Surgery
SUNY Upstate Medical University,
Syracuse, New York
* Bellemans, 1999
Based on the following sources:
Changoor et al., 2004 (horse); Shepherd and Seedhom, 1997 (human); Jackson et al., 2001 (goat); Lane et al., 2004 (goat); Gelse et al., 2003 (rat); Oakley et al., 2004 (sheep); Hunziker and Rosenberg 1996 (rabbit, minipig)
Hunziker and Quinn, 2003
Thickness Density Extent of the Defect
Human Rabbit Goat
H R G H R G
0% 95% 85%
from Hunziker, 1999
Trochlea groove Regeneration
Femoral condyleLocation of Defects
*Lane et al., 1999
“Although the repair of articular cartilage defects has been studied in many species including rabbits, goats, and sheep, there is no consensus on the most appropriate
“…none of these species replicate the anatomical, cellular, and biomechanical properties of the human knee. Therefore, we selected the most closely related species, a nonhuman primate (NHP), that may exhibit a healing response most similar to that of humans….”
Gill et al., AJSM, 2005