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ENABLING TRANSLATION INSTITUTE FOR CANCER/STEM CELL BIOLOGY AND MEDICINE. Stanford School of Medicine Leadership Retreat January 29-31, 2004. Background. Created in December 2002 Purpose: To advance fundamental research in cancer and stem cell biology

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slide1
ENABLING TRANSLATION

INSTITUTE FOR CANCER/STEM CELL BIOLOGY AND MEDICINE

Stanford School of Medicine Leadership Retreat

January 29-31, 2004

background
Background
  • Created in December 2002
  • Purpose:
    • To advance fundamental research in cancer and stem cell biology
    • To translate discoveries to preclinical paradigms
    • To organize efforts throughout the University
      • To enhance our understanding of human diseases
      • To improve patient care
  • Past Stanford-affiliated Accomplishments:
    • First prospective isolation of mouse hsc (1988)
    • First isolation of human hsc (1991)
    • First isolation of mouse and human hematopoietic progenitors (2000)
    • First prospectively isolated brain-forming (CNS) stem cells (2000)
    • Fruit fly sperm-forming stem cell identified (1999)
discovery translation therapy
Discovery => Translation => Therapy

Example: Breast Cancer

  • Cancer-free human stem cells isolated and stored from patients with Stage IV breast cancer
  • Post-chemotherapy, stored hsc used to regenerate blood-forming system in patients
  • Blood-forming system regenerated in ≈ 2 weeks
  • Survival rates and cancer recurrence rates are much higher than expected from normal therapies
  • Future: Search for breast cancer stem cells, and define targets for diagnosis, molecular therapeutics, and immunotherapeutics by expression arrays and proteomics.
  • Similar experiences with non-Hodgkin’s Lymphomas
discovery translation therapy4
Discovery => Translation => Therapy

Promising Animal Models (at Stanford) for studying and using hematopoietic and CNS stem cells, and new tissue stem/progenitor cells:

  • Spinal Cord Injury, Cerebrovascular stroke
  • Genetic diseases leading to brain degeneration
  • Transplant Rejection improvements in
    • Heart Transplants
    • Pancreatic Insulin-Producing Islet Cells
    • Skin Grafts
    • Liver
  • Juvenile Type 1 diabetes
  • Infectious diseases of CNS (Arvin) and BMT (Brown)
new stem cell opportunities
New Stem Cell Opportunities

Through the Institute for Cancer/Stem Cell Biology and Medicine, we will:

  • Identify and recruit the best young stem cell biologists who wish to find new organ or tissue stem cells (lung, peripheral nervous system, skin, liver, pancreas, kidney, etc.)
  • Identify and appoint Associates and Affiliates.
  • Develop Affiliate ‘hotel’ space in CSCI to improve collaborations.
  • Establish research models to produce human pluripotent stem cells from patients with genetically determined diseases
  • Provide specialized research models and rigor to do it right the first time
  • Provide specialized instrumentation
  • Provide a vehicle for deeply-interested physicians, residents, graduate students, postdocs and, under the new curriculum, medical student scholars to form translational teams.
  • Establish educational programs for larger community.
comprehensive cancer center role
Comprehensive Cancer Center Role
  • Discovery of cancer stem cells and the protooncogenes activated in them is a convergence of:
    • Classic stem cell biologists
    • Classical cancer gene biologists
    • Cancer and Leukemia oncologists
  • Stanford approach to cancer and cancer stem cell biology:
    • Recruit 1 or more of the best cancer stem cell biologists in the world
    • Extend the tools of cancer stem cell biology to each of the cancers commonly treated at Stanford
    • Recruit to Stanford 1-2 of the best cancer gene biologists
    • Establish Stanford as an NCI-designated Comprehensive Cancer Center and recruit and outstanding leader
slide7
The new Stanford Cancer Center, the Institute and NCI

designation create a comprehensive approach to cancer:

Stanford

Hospital & Clinics

& LPCH

Clinical Care

School of Medicine

Research

Institute for Cancer/Stem Cell Biology and Medicine

Translational

NCI-Designated Comprehensive Cancer

Center

Research

slide8
Examples of Current Translational Collaborations

NEW COLLABORATIVE RESEARCH PROGRAMS TO IDENTIFY AND ISOLATE HUMAN CANCER AND LEUKEMIA STEM CELLS

  • Brain Cancers: Griff Harsh, Steve Huehn, Steve Skirboll,Victor Tse, Sam Cheshier
  • Ovarian Cancers: Nelson Teng, Amreen Hussein
  • Lung Cancers: Glenn Rosen
  • Bladder, Prostate, and Kidney Cancers: Joe Presti, Linda Shortliffe
  • Uterine Cancers and Endometriosis: Linda Giudice
  • Acute and Chronic Myelogenous Leukemias: Catriona Jamieson, Robert Lowsky, Peter Greenberg
  • Breast Cancers: Matt van der Rijn, Michael Clarke (Michigan), Stephanie Jeffries, Jonathan Pollock
  • Head and Neck (tentative): Fee, Goode, Quynh-Thu Le
slide9
Examples of Current Translational Collaborations

COLLABORATIONS TO FIND TISSUE STEM CELLS

  • Pancreatic islets: Seung Kim and Roel Nusse
  • Cerebellum: Matt Scott
  • Bladder: Linda Shortliffe
  • Endometrium: Linda Giudice
  • Mesenchymal: Mike Longaker
  • Neural: Bill Mobley and Ann Arvin (ID)
  • Cardiac: Bobby Robbins
  • Hematopoietic progenitors: Wes Brown (ID)
examples of current translational collaborations
Examples of Current Translational Collaborations

COLLABORATIONS TO FIND PROGENITOR CELLS IN THE IMMUNE SYSTEM

  • Dendritic cells: Ed Engleman and Miriam Merad
  • Precursor T cells: Sam Strober
  • Precursor B cells: Erik Ranheim
  • Marrow-engrafting facilitator cells: Judy Shizuru
current translational collaborations examples
Current Translational Collaborations: Examples

IMAGING AND EXPANDING BLOOD-FORMING STEM CELLS

  • Imaging: Chris Contag, Sam Gambhier
  • Expansion: Roel Nusse, Mark Kay
priority hires over next several years
Priority hires over next several years
  • Cancer Center Director (in progress)
  • Senior appointment in pluripotent stem cell biology (as soon as space is available)
  • Senior Cancer Stem Cell Physician Scientist (as soon as space is available)
  • Cancer gene scientist in collaboration with Cancer Center Director (in 1-3 years, if space is available)
  • Junior stem cell biologists (in 1-4 years as space becomes available); best possible at a fundamental level, but optimally in a field that can be translated
next steps
Next Steps
  • Help raise funds for SIM 1
  • Raise funds for CSCI recruitments, endowments, common core specialized instrumentation, funding for ‘hotel space’ labs in CSCI.
  • Recruitments as detailed.
  • With Steering Committee, begin process of identifying internal candidates for Associate positions in CSCI.
  • With Steering Committee canvas current university faculty for Affiliate positions in CSCI, and choose affiliates.
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