Viral Disease in Ruminant. Sukolrat Boonyayatra DVM, M.S. Clinic for Ruminant, FVM. CMU. Disease topic including:. Bovine Ephemeral Fever Bovine Respiratory Syncytial Virus Parainfluenza-3 Bovine Viral Diarrhea Infectious Bovine Rhinotracheitis Foot and Mouth Disease
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Clinic for Ruminant, FVM. CMU.
(Three-day sickness, Bovine Epizootic Fever, Three-day stiffsickness,
Dragon boat disease)
1. Genus Vesiculovirus
Type Species vesicular stomatitis Indiana virus
2. Genus Lyssavirus
Type Species rabies virus
3. Genus Ephemerovirus
Type Species Bovine ephemeral fever virus
4. Genus Cytorhabdovirus
Type Species lettuce necrotic yellows virus
5. Genus Nucleorhabdovirus
Type Species potato yellow dwarf virus
Drag feet when forced to walk
Lying down, with hide limbs outstretched-
to relieve muscle cramp
Lie down for three days
Recovery period3-4 wks.
“Single stranded RNA virus that replicate in the cytoplasm and mature by budding from apical cell membrane”
Lung. Multinucleated syncytial cell is prominent within the bronchiole and appears to be arising from the epithelial layer. The lumen is packed with neutrophils. A few neutrophils are also transmigrating the bronchiolar wall and are in the adjacent atelectactic parenchyma. 40X
Antigen Detection Enzyme Immunoassay
Immunofluorescent Antibody Staining
Detection of Nucleic acids: PCR
- Pasteurella haemolytica
Inactivated BRSV vaccine
Killed vaccine protects against IBR, BVD, PI3 and BRSV, and Pasteurella haemolytica and Haemophilus.
- Bovine herpesvirus type1 (IBR)
- Bovine herpesvirus type3 (malignant catarrhal fever virus)
- Bovine herpesvirus type4 (DN-599, Movar 33/63)
- Bovine adenovirus types1 to 8
- Bovine parainfluenza virus type3
- Bovine respiratory syncytial virus
- Bovine viral diarrhea virus
- Reovirus types1 to 3
- Bovine Rhinovirus types1 and 2
- Bovine Enterovirus types1 to 7
- Influenza virus (reported from Russia)
Mycoplasma mycoides subspecies mycoides
- Chlamydia psittaciInfectious Agents Identified in the Bovine Respiratory Disease Complex
2 biotypes: cytopathogenic (cp) or noncytopathogenic (ncp)
Both biotypes of BVDV infect cattle and cause disease, but only ncp BVDV causes persistent infections.
0-40 Embryonic death
40-120 Abortion or
Persistent Infected calf
90-160 Abortion or
160-Parturition Abortion or normal calf
Both groups of animal are considered as source of infection in herd.
Seroprevalence Antigen/virus isolation
United Kingdom + +
Germany NK +
Denmark + +
Sweden + +
Norway + NK
United state + +
Thailand +(Bulk milk) NK
NK: Not Known
Mild infection: off feed, depressed, mild diarrhea and recovery
Subclinical infection with no visible signs are most common
Colostral antibodies protect most calves until 4-8 months
Figure 1: Choroid plexus, filly: EHV-1 within endothelium and circulating macrophages. Peroxidase immunohistochemistry and hematoxylin.
Figure 2: Lung, calf persistently infected with bovine pestivirus (BVD virus) with bacterial bronchopneumonia. BVDV is contained within the cytoplasm of numerous cells (macrophages, endothelia, alveolar epithelium). Peroxidase immunohistochemistry and hematoxylin.
Infectious balanoposthitis (IBP)
widespread tumour metastasis
sometimes extension into the thorax
Young adults develop superficial cutaneous tumour that disappear spontaneously after a few weeks.
- calves < 6 mths old can be false positive
4% of Sodium carbonate
BSE, Mad cow disease
The wild type prion (PrPc) is found in the secretory pathway of
cells expressing the protein(1)and moves to the plasma
membrane where it is anchored by its GPI tail (2).There it may
bind to an extracellular ligand (possibly copper) (3) before being
cycled from the membrane into endocytic vesicles (4). At some
point its cargo is released and the protein either passes to the
lysozome for degradation or back to surface for another round of
ligand binding. In this respect it resembles many other
membrane-resident proteins. The pathogenic form(PrPSc) also
finds its way to endocytic vesicles where it co-opts some of the
wild type form to become pathogenic (5). PrPSc is resistant to
degradation, a hallmark of the infectious form, so accumulates.
Neurotoxicity is probably linked to the conversion event itself,
perhaps through its interference with normal PrPc turnover,
because there is considerable evidence to show that the accrued
PrPSc is not inherently toxic.
in the early stage of RP infection.
in the early stage
of RP infection.
of lesions (hemorrhage) at the ceco-colic junction
of the colon - Zebra striping
The Global Rinderpest Eradication Program (FAO)
Pseudo-urticaria, Neethling virus disease, exanthema nodularis bovis, knopvelsiekte
abortion, intrauterine infection, and temporary sterility in bulls and cows may occur.
in Egypt affected with LSD
and interlobular edema
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