Osteoporosis. Osteoporosis: Scope of the Problem. Osteoporosis is characterized by low bone mass and micro architectural deterioration of bone tissue, leading to bone fragility and an increase risk of fracture 10 million individuals already have osteoporosis. .
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* Personal history of fracture as an adult
* History of fracture in first degree relative.
* Low Body Weight (<127 lbs)
Early Menopause (<45 yr) or
Excess alcohol intake
Low calcium intake
Inadequate physical activity
Poor health, poor eyesight and recurrent falls.Risk Factors in Osteoporosis
Compares the BMD measured to the BMD of individuals who are at peak bone mass. Usually at age 35 years
Predicts the patient’s risk of fracture
Aka “% young adult”
Compares the BMD measured with the BMD or age matched peers
Indicates if factors other than age may be affecting the patient’s BMD
Aka “% age matched”BMD Details: Two Additional Measures
Increases Bone Mineral Density
Decreases total cholesterol and LDL cholesterol
Binds to sites in uterus and breast
No uterine stimulation
No uterine cancer risk
No need for provera (progesterone)
No breast stimulation
No breast tendernessEvista: Molecule With Two Active Binding Sites