1 / 78

Urinary Path Review

Urinary Path Review. Normal Prostate. Two components of the prostate: Glands Stroma Glands have 2 type of cells: Basal luminal. Normal prostate. Note the two cell layers and continuous layer of basal cells. The presence of basal cells indicates benignity.

Leo
Download Presentation

Urinary Path Review

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Urinary Path Review

  2. Normal Prostate Two components of the prostate: • Glands • Stroma Glands have 2 type of cells: • Basal • luminal

  3. Normal prostate • Note the two cell layers and continuous layer of basal cells. • The presence of basal cells indicates benignity

  4. What markers and staining do the basal cells have?

  5. Basal cells stain with high molecular weight cytokeratin, PSA - and PAP - What about the luminal cells?

  6. Luminal cells are PSA + and PAP+

  7. Which zone of the prostate is the area of hyperplasia?

  8. Transitional Zone, periurethral • In which zone do most carcinomas arise?

  9. Peripheral Zone • Makes up the bulk of the gland • Easiest area to biopsy and feel with DRE • What’s the third zone called?

  10. Central zone; resistant to pathology. Like me.

  11. Point to the zones

  12. Transitional Zone Peripheral Zone

  13. What is the enzyme that converts testosterone into DTH?

  14. 5 alpha reductase. In the prostate this enzyme converts the testosterone secreted by the leydig cells of the testes into DTH. Receptor are located in the stroma. Testosterone receptors are in the epithelium.

  15. What’s the hallmark of acute prostatitis? Neutrophils

  16. Granulomatous Prostatitis Key here is the presence of giant cells and macrophages. Response to rupture of intraluminal contents or TB/fungi.

  17. Benign Prostatic Hyperplasia Note the nodular appearance and the slit-like shape of the urethra due to compression

  18. Prostatic intraepithelial neoplasia • Precursor to invasive carcinoma of the prostate • Intraductal lesion

  19. Normal prostate Stained with high molecular weight cytokeratin. Note the continuous layer of staining around the glands

  20. Benign prostatic hyperplasia More stroma, more glands, more cellular, more dilated

  21. Prostatic intraepithelial neoplasia HMWC stain: interruptions in the basal cell layer. Precursor lesion to adenocarcinoma of the prostate.

  22. Prostate Carcinoma • Most often in peripheral zone • Most often adenocarcinoma • Firm yellow white nodule on gross

  23. T/F: the prostate is necessary for reproduction/fertility False. The prostate secretes bacterialcidal liquid that activates the sperm, but is not necessary for sperm viability.

  24. Cystitis • This is acute inflammation

  25. Prostate adenocarcinoma • Lots of small glands

  26. Prostate adenocarcinoma Grade 5: undifferentiated. Can’t even tell it’s adeno. Fused masses of malignant cells

  27. Common sites of prostate CA metastases: • Bone (blastic lesions, not lytic lesions) • Lymph nodes • Invasion is often by perineural invasion

  28. Prostate CA Perineural invasion

  29. Adenocarcinoma of the prostate • Note that the malignant glands lack the HMWK stain…absence of basal cell layer is bad.

  30. Prostatic Abscess • Look for this when you are diagnosing acute bacterial prostatitis. • Important to find because antibiotics won’t penetrate the abscess. • Treatment for acute bacterial prostatitis is usually with Quinolones.

  31. Bladder Wall • Image shows the various layers • Urothelium • Lamina propria • Muscularis propria

  32. Urothelium • Note the superficial umbrella cells…big and broad…

More Related