Opioid Analgesics. Mallika Doss April 10, 2008. Overview. History Morphine SAR of Morphine Drug Dissection of Morphine Morphine Analogues Opioid Receptors & Receptor Binding Agonists and Antagonists Why you feel “happy” Endogenous Opioid peptides The Future. The History.
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April 10, 2008
Double bond at 7-8
Loss of activity
Equatorial Antagonist binding area
Axial Agonist binding area
Most strongly binds morphine
Best bet for a safe analgesic