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Suspected Ectopic Pregnancy Obstetrics & Gynecology vol. 107, No2 part 1, February, 2006 OBGY R2 BYUN JUNG MI Suspected Ectopic Pregnancy Abstract Incidence Risk factors Diagnostic Approach Therapeutic Approach Follow-up Abstract

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Suspected Ectopic Pregnancy

Obstetrics & Gynecology vol. 107, No2 part 1, February, 2006


suspected ectopic pregnancy
Suspected Ectopic Pregnancy
  • Abstract
  • Incidence
  • Risk factors
  • Diagnostic Approach
  • Therapeutic Approach
  • Follow-up
  • Women who present with pain and bleeding in the first trimester are at risk for ectopicpregnancy, a life-threatening condition.
  • Predisposal condition

: damaged fallopian tubes from prior tubal surgery or previous pelvic infection,

smoking, conception using assisted reproduction.

  • Many women without risk factors can develop an ectopicpregnancy.
  • A diagnostic algorithm : use of
    • transvaginal ultrasonography,
    • human chorionic gonadotropin (hCG) concentrations
    • sometimes, uterine curettage
  • When the initial hCG value is low, serial hCG values can be used to determine whether a gestation is potentially viable or spontaneously resolving.
  • The minimal rise in hCG for a viable pregnancy : 53% in 2 days.
  • The minimal decline of a spontaneous abortion : 21–35% in 2 days, depending on the initial level.
    • A rise or fall in serial hCG values that is slower than this is suggestive of an ectopicpregnancy.
  • Treatment

- medical management with methotrexate

(for unruptured ectopic pregnancy )

: used to safely treat an ectopicpregnancy with success

rates, tubal patency rates, and future fertility that are

similar to those obtained with conservative surgery.

: Success rates using methotrexate

- inversely rated to baseline hCG values

- higher using "multidose" compared with "single-dose“ regimens.

- Surgical treatment

: may be conservative or definitive and should be attempted in

most cases via laparoscopy.

ectopic pregnancy
Ectopic pregnancy
  • Definition

: The implantation of a fertilized ovum outside the endometrial cavity,

continues to be a major cause of morbidity and mortality in reproductive-

age women.

  • Prevalence

: 2% of pregnancies in the United State

  • If undiagnosed and/or untreated

: accounting for about 9% of maternal pregnancy-related deaths in U.S.

(result in rupture of the fallopian tube and massive intraperitoneal

hemorrhage )

  • Between 1970 and 1992, a 6-fold increase was seen in the number of ectopic pregnancies diagnosed in the U.S.
    • earlier, more accurate diagnosis of pregnancies.
    • increased incidence of sexually transmitted infections
    • earlier diagnosis of pelvic inflammatory disease resulting in tubal damage but not complete blockage
    • rise in the number of ectopic pregnancies resulting from assisted reproductive technologies(ART)

→ may account for the overall increase.

  • Incidence of tubal pregnancy after oocyte retrieval / embryo transfer may be as high as 4.5% (by Maymon and Shulman)
  • Incidence of heterotopic pregnancy

: about 1:4000 in the general population

1:100 in in vitro fertilization (IVF) pregnancies

(much higher than the originally described prevalencies of

1:30,000 in the late 1940s’)

-> Due to the increasing use of ovulation induction agents that increase

the chance of twinning and may cause hormonal fluctuations

affecting tubal motility, and also due to the invasive nature of ART.

risk factors
Risk Factors
  • Impede the migration of the fertilized ovum to the uterus
    • Damage to the fallopian tube from prior pelvic inflammatory disease
    • History of ectopic pregnancy and previous tubal surgery, including previous tubal ligation

Cigarette smoking (thought to affect tubal motility)

    • Increasing age

more than one lifetime sexual partner

weakly linked to an increased risk of ectopic pregnancy.

  • No clear association has been documented between ectopic pregnancy and oral contraceptive use, previous elective pregnancy termination, spontaneous miscarriage, or cesarean delivery.

Fig.1. Possible anatomic sites in ectopic pregnancies. Illustration :John Yanson.Seeber. Suspected Ectopic Pregnancy. Obstet Gynecol 2006.

diagnostic approach
Diagnostic Approach
  • Symptoms

: abdominal or pelvic pain and vaginal bleeding in the first trimester

of pregnancy (m/c)

* Nonspecific : spontaneous miscarriage, cervical irritation or

trauma, and infection

  • Physical examination
    • hypotension and tachycardia with rebound tenderness and guarding

→ tubal rupture with immediate need for surgical intervention

  • ß-hCG
  • USG (transvaginal sonography)
  • Evacuation of Uterine contents
  • Progesterone
diagnostic approach steps to diagnosis
Diagnostic Approach-Steps to Diagnosis -
  • Transvaginal ultrasound examination
    • Gestations >51/2 weeks should identify an intrauterine pregnancy with near 100% accuracy.
    • Geataional sac (‘double decidual sign’ at 41/2~5weeks after the LMP)
    • Yolk sac (at 5 weeks)
    • Fetal pole with later cardiac motion (at 51/2~6weeks)
diagnostic approach discriminatory cutoff
Diagnostic Approach- Discriminatory Cutoff-
  • Definition

: level of ß-hCG at which a normal intrauterine pregnancy can be

visualized by ultrasonography with sensitivity approaching 100%

  • above the discriminatory cutoff of 1,500~2,500 IU/L, using transvaginal ultrasonography, a normal intrauterine pregnancy should always be visualized.
diagnostic approach discriminatory cutoff14
Diagnostic Approach- Discriminatory Cutoff-

Varying the discirminatory cutoff will affect the sensitivity and specificity for diagnosis

In our view, it is better to set the discriminatory cutoff high, especially in a population of stable patients who maintain close medical follow-up.

diagnostic approach fig 2 diagnostic algorithm for ectopic pregnancy
Diagnostic Approach(Fig. 2. Diagnostic algorithm for ectopic pregnancy. )

Early Pregnancy with pain / bleeding

Expectant management

Intrauterine pregnancy

Treat ectopic pregnancy


Ectopic pregnancy

Abnormal intrauterine pregnancy


Expectant management vs D&C vs intravaginal misoprostol


>discrminatory zone

(no intrauterine pregnancy)

< discriminatory zone

No treatment

Abnormal rise or fall

Evaluation of uterine contents

Serial ß-hCG

Normal fall

No chorionic villi

Chorionic villi (Dx: Abnormal intrauterine pregnancy)

Normal rise

Uttrasound when ß-hCG > discriminatory zone (back to top)

Treat ectopic pregnancy

diagnostic approach human chorionic gonadotropin above discriminatory cutoff
Diagnostic Approach- Human Chorionic Gonadotropin Above Discriminatory Cutoff-
  • Diagnosing an ectopic pregnancy based solely on serial ß-hCG levels that are declining abnormally below the discriminatory zone is inaccurate in up to 31% of cases.

if pathological examination : not available

→ß-hCG may be checked approximately 12-24hrs later

if the level does not drop significantly on the day after uterine evacuation,

→ an extrauterine gestation is diagnosed.

  • We use a drop of 15% as the minimal needed but normally see a much steeper drop if the pregnancy tissue has been successfully removed.
  • To definitively confirm resolution of the pregnancy in the absence of tissue diagnosis, ß-hCG values should be followed at least weekly until undetectable, a process that may take up to several weeks.
diagnostic approach human chorionic gonadotropin below discriminatory cutoff
Diagnostic Approach- Human Chorionic Gonadotropin Below Discriminatory Cutoff-
  • initial ß-hCG < the discriminatory zone

→ serial ß-hCG measurements are needed to document a growing

(potentially viable) or a nonviable pregnancy.

  • The minimum rise for a potentially viable pregnancy that presents with pain and/or vaginal bleeding is 53%, based on the 99th percentile confidence interval(CI) around the mean of the curve of ß-hCG rise over time

→ followed with serial ß-hCG levels until an intrauterine pregnancy

was confirmed.

diagnostic approach human chorionic gonadotropin below discriminatory cutoff18
Diagnostic Approach- Human Chorionic Gonadotropin Below Discriminatory Cutoff-
  • Intervention for a ß-hCG rise of less than 66% over 2days, a practice supported by previous data, would potentially result in the interruption of many viable pregnancies.
  • If the ß-hCG does not rise appropriately, or declines, a nonviable pregnancy has been diagnosed.
  • A rapid decline in ß-hCG value is consistent with a miscarriage that may resolve spontaneously.
  • If the ß-hCG does not fall 21~35% in 2days (depending on the initial value), → suspected ectopic pregnancy. @
diagnostic approach definitive diagnosis
Diagnostic Approach-Definitive Diagnosis-

More than 70% of women who have an ectopic pregnancy will have

- a rise in hCG that is

slower than the minimal

rise for a viable pregnancy


- a decline that is slower

than the minimal rate of

fall in a spontaneous


hCG rises like an IUP in 21% of EP

hCG falls like an SAB in 8% of EP

diagnostic approach progesterone
Diagnostic Approach-Progesterone-
  • Debated.
  • Progesterone levels are higher in intrauterine pregnancies

: no well-established upper cutoff to use to discriminate

diagnostic approach novel diagnostic methods
Diagnostic Approach-Novel Diagnostic Methods-
  • develop a serum-based test that relies on placental or pregnancy-specific markers* elevated levels of vascular endothelial growth factor (VEGF) have been noted 11days after embryo transfer during IVF cycles in ectopic gestations, but with rather low predictive values.
    • Pregnancy-associated plasma protein A (PAPP-A)
    • Pregnancy-specific B1-glycoprotein
    • human placental lactogen (hPL)
    • hCG
    • anonplacental markers - glycodelin, VEGF and progesterone
diagnostic approach novel diagnostic methods22
Diagnostic Approach-Novel Diagnostic Methods-
  • One study

: VEGF + PAPP-A + progesterone

→discriminate ectopic pregnancy from intrauterine pregnancy

: sensitivity : 97.7% / specificity : 92.4%

(although this discriminative power was lower for early gestations. )

  • Other markers- not appear useful in the clinical setting at this point-

: creatinine kinase, fetal fibronectin, leukemia inhibitory factor, smooth

muscle heavy-chain myosin and CA125.

therapeutic approach
Therapeutic Approach
  • minimally invasive surgery or medical therapy

→These treatment modalities have been shown to have success rates

comparable to the gold-standard treatment of laparotomy with salpingectomy,

but with the potential benefit of fallopian tube conservation.

  • Laparotomy

: therapy for hemodynamically unstable patients

with high suspicion of tubal rupture.

therapeutic approach methotrexate
Therapeutic Approach-Methotrexate-
  • Class of drugs called folic acid antagonists
  • History
    • Initially used for treating leukemia, it gained wide use in gynecology for the treatment and cure of choriocarcinoma
    • First introduced as a novel therapy for ectopic pregnancy in 1982.
  • Action mechanism

; by inactivating the enzyme dihydrofolate reductase (DHFR), leading to

depletion of the cofactors required for DNA and RNA synthesis.

  • Goal of medical management with MTX

: to selectively kill the cytotrophoblasts, the rapidly dividing cells at the

fallopian tube implantation site.

→ The body will then spontaneously resorb the remaining products of

conception and blood clot that constitute the ectopic pregnancy.

therapeutic approach methotrexate25
Therapeutic Approach-Methotrexate-
  • Leucovorin( folic acid )

: used as a “rescue” medication

- allows for higher MTX dose administration by preventing some of the

otherwise prohibitive adverse effects.

  • Administration

: oral, intramuscular, intrathecal, or by continuous infusion

    • In ectopic pregnancy : IM is preferred, although there have been reports of success with the oral route.
  • It may be used as primary treatment of (Indication)
    • persistent ectopic pregnanacy after salpingostomy
    • prophylaxis for suspected persistent products of conception after conservative surgery
    • in cases of unusually located ectopic pregnancies.
therapeutic approach methotrexate dosing regimens
Therapeutic Approach-Methotrexate Dosing Regimens-

<Protocol >

Multidose regimen

- MTX : 1mg/kg per day, IM, on days 1,3,5, and 7

- leucovorin : 0.1mg/kg , IM, on days 2,4,6 and 8

* Surveillance : ß-hCG should be checked every 7days until ß-hCG,<5

therapeutic approach methotrexate dosing regimens27
Therapeutic Approach-Methotrexate Dosing Regimens-

<Protocol >

Multidose regimen

  • Patients are given up to 4 doses (1MTX, 1leucovorin) until the ß-hCG decreases by at least 15% on 2 consecutive days
  • 2nd course after one week may be given if there is an increase or plateau in 2 consecutive ß-hCG values
therapeutic approach methotrexate dosing regimens28
Therapeutic Approach-Methotrexate Dosing Regimens-

<Protocol >

Single-dose regimen

- MTX : 50mg/m2 , IM , not use leucovorin rescue.

Surveillance : ß-hCG should be checked every 7days until ß-hCG <5

  • 2nd dose may be administered after 1week if ß-hCG values do not decline by
  • at least 15% between days 4 and 7 after treatment
  • Using the “single-dose” protocol, approximately 20% of women require more
  • than one treatment cycle.
therapeutic approach methotrexate dosing regimens29
Therapeutic Approach-Methotrexate Dosing Regimens-
  • Regardless of the MTX regimen used, patients need to be followed weekly with surveillance ß-hCG after their treatment until ß-hCG is undetectable in serum.

→ only way to confirm complete resolution of the ectopic pregnancy

→ It is important to be aware that ectopic pregnancies may cause tubal

rupture even when the ß-hCG levels are on their way down.

  • Specifically, in situations where the ß-hCG increased at least 66% over 48 hours before MTX administration

→the tubal rupture risk : as high as 20%.

therapeutic approach effectiveness of methotrexate
Therapeutic Approach-Effectiveness of Methotrexate-
  • based on 12 studies with at least 20 patients each, the authors concluded that MTX treatment has been shown to be successful in 78~96% of selected patients,

→ posttreatment hysterosalpingogram-documented tubal patency : 78%,

65% : subsequent pregnancy succeeded

13% : incidence of recurrent ectopic pregnancy.

- Reviewed by Pisarska et al

therapeutic approach single dose versus multidose
Therapeutic Approach-Single Dose Versus Multidose-
  • Recent meta-analysis

: Barnhart et al (data from 26 articles that met their search criteria, reviewing 1.327 cases of

women diagnosed with ectopic pregnancy who were treated with MTX)

- overall success rate for the use of methotrexate : 89%

- considering each regimen separately,

    • the success rate of “multidose” therapy : 92.7%with a 95 CI of 89~96%
    • for “single-dose” : 88.1%with a 95% of 86~90%, a statistically significant difference.
  • Importantly, when the frequency of failure was compared, controlling for initial hCG value and the presence of embryonic cardiac activity, the failure rate with single-dose therapy was almost 5 times greater (95%CI)
therapeutic approach single dose versus multidose32
Therapeutic Approach-Single Dose Versus Multidose-
  • New protocol
    • 2 doses of MTX (on day 1 and day 4) without leucovorin rescue
    • using the follow-up of the single-dose protocol may more optimally balance convenience and efficacy.
therapeutic approach single dose versus multidose33
Therapeutic Approach-Single Dose Versus Multidose-

Absolute Contraindications to Medical Therapy With Methotrexate

  • Breastfeeding
  • Overt or laboratory evidence of immunodeficiency
  • Alcoholism, alcoholic liver disease, or other chronic liver disease
  • Preexisting blood dyscrasias, such as bone marrow hypoplasia, leukopenia, thrombocytopenia, or significant anemia
  • Known sensitivity to methotrexate
  • Active pulmonary disease
  • Peptic ulcer disease
  • Hepatic, renal, or hematologic dysfunction

Relative contraindications

  • Gestational sac 3.5cm or greater
  • Embryonic cardiac motion

Adapted from American Colleage of Obstetricians and Gynecologists Medical Management of Tubla Pregnancy. ACOG Practice Bulletin 3. Washington, DC ; ACOG ; 1998.

therapeutic approach single dose versus multidose34
Therapeutic Approach-Single Dose Versus Multidose-
  • Premedicational preparation
    • CBC, LFT, and S/E especially Scr
    • Chest X-ray : if, Hx of pulmonary disease(+)
    • discontinue folic acid supplements and prenatal vitamins.

★ When using the multidose protocol, the above laboratory studies should be

repeated 1 weekafter the last dose of MTX.

therapeutic approach predictors of success
Therapeutic Approach-Predictors of Success-
  • Initial serum ß-hCG level (most predictive)
  • progesterone level,
  • size and volume of the gestational mass,
  • presence or absence of cardiac activity,
  • presence or absence of free peritoneal blood
therapeutic approach predictors of success36
Therapeutic Approach-Predictors of Success-
  • Treatment failure
    • 65% of cases : ß-hCG level > 4,000 IU/L
    • 7.5% : ß-hCG < 4.000 IU/L. -Tawfiq et al
  • Median pretreatment serum ß-hCG level was lower in women in whom treatment was successful compared with women with treatment failures

(773 vs 3.802 mIU/mL) –Potter et al

  • Recent review of 350 women treated with single-dose MTX for ectopic pregnancy found that the only factor that contributed significantly to the failure rate was ß-hCG level before treatment

* >5,000 mIU/mL: the failure rate rose to about 13%

- No absolute level at which medical management is contraindicated.

  • We currently use the multidose protocol or the new “2-dose protocol” to

treat women with a hCG above 1,000mIU/mL

therapeutic approach post methotrexate follow up
Therapeutic Approach-Post-Methotrexate Follow-up-
  • abdominal pain6-7 days after receiving the medication (33% ~ 60% of patients )
    • result from tubal abortion or hematoma formation with distention of the

fallopian tube.

    • can be treated conservatively with pain medications and close follow-up and do not require surgical intervention.
  • if there is evidence of tubal rupture with bleeding, as evidenced by declining hemoglobin levels or ultrasound visualization.

→ Surgery

  • the ß-hCG level may plateau, or even rise, before it begins to fall.

→ explained by the fact that, although MTX arrests mitosis in the cytotrophoblasts, the syncytiotrophoblast continues to increase and produces hormone.

therapeutic approach post methotrexate follow up38
Therapeutic Approach-Post-Methotrexate Follow-up-
  • ultrasound examination

: may show an increase in the ectopic size and possibly an increase in

vascularity before resolution.

  • increases in ectopic size were not associated with failure of treatment.

-Atri et al

→not necessary to follow patients with serial ultrasound examinations once

they have received MTX treatment

→ ultrasound findings would not alter management unless a new tubal rupture

is seen.

therapeutic approach post methotrexate follow up39
Therapeutic Approach-Post-Methotrexate Follow-up-

Signs of Treatment Failure and/or Tubal Rupture

  • Significantly worsening abdominal pain, regardless of change in ß-hCG level
  • Hemodynamic instability
  • Levels of ß-hCG that do not decline by at least 15% between day 4 and day 7 postinjection
  • Increasing or plateauing ß-hCG levels after the first week of treatment

Adapted from American Colleage of Obstetricians and Gynecologists Medical Management of Tubla Pregnancy. ACOG Practice Bulletin 3. Washington, DC ; ACOG ; 1998.

therapeutic approach methotrexate for extratubal ectopics
Therapeutic Approach-Methotrexate for Extratubal Ectopics-
  • Used for ectopic pregnancies located outside the fallopian tube

(cervical, interstitial, ovarian, or abdominal gestations)

: first-line treatment d/t the difficulty and risk of surgical resection

  • MTX use for cervical ectopic

: one review included 36 women treated with systemic MTX, local injection of MTX or potassium chloride(KCl) or a combination of these therapies

→ 80~90% success rate.

  • Interstitial pregnancy : 83%
therapeutic approach complications of methotrexate
Therapeutic Approach-Complications of Methotrexate-
  • Folic acid analogue

: affects rapidly dividing cells

( esp. those of the gastrointestinal tract and the bone marrow )

  • Major adverse effects

impaired liver function



bone marrow suppression

therapeutic approach complications of methotrexate42
Therapeutic Approach-Complications of Methotrexate-
  • Multidose regimen(100)

: sotmatits(2), elevated liver transaminases (3) - spontaneously resolved

--reported by Stovall et al

  • Single-dose regimen(120)

: nausea and vomiting (1)

-- reported by Barnhart et al

  • Prevalence of adverse effects of about 30~40% using the “single-dose” and “multidose” regimens finding no difference between the two once they adjusted for ß-hCG values (table3.) their meta-analysis

Adapted from Barnhart KT, Gosman G, Ashby R, Sammel M. the medical management of ectopic pregnancy ; a meta-analysis comparing “single dose’ and ‘multidose’ regimens. Obstet Gynecol 2003;101:778-84

therapeutic approach complications of methotrexate43
Therapeutic Approach-Complications of Methotrexate-

Adverse Effects associated with Methotrexate Treatment

  • Drug Adverse Effects
  • Nausea
  • Vomiting
  • Stomatitis
  • Gastric Distress
  • Dizziness
  • Severe neutropena (rare)
  • Reversible alopecia(rare)
  • Pneuminitis
  • Treatment Effect
  • Increase in abdominal pain
  • Increase in ß-hCG levels during
  • first 1-3days of treatment
  • Vaginal bleeding or spotting

Adapted from Amnerican College of Obstetricians and Gynecologists. Medical Management of Tubal Pregnancy.

ACOG Practice Bulletin 3. Washington, DC;ACOG;1998.

therapeutic approach surgical resection
Therapeutic Approach-Surgical Resection-
  • Laparotomy

: reserved for cases of extensive intraperitoneal bleeding with intravascular

compromise due to active bleeding, where hypovolemic shock must be


  • Open surgical approach : may be preferable include

- extensive pelvic adhesions

: adequate visualization of the ectopic is impossible

- extra-tubal, intra-abdominal ectopic gestations where risk of injury to

other pelvic structures is high.

therapeutic approach surgical resection45
Therapeutic Approach-Surgical Resection-
  • Laparoscopic approach
    • decreased surgical blood loss, a decrease in the amount of analgesic used, and shorter postoperative hospital stay.

(compared with laparotomy)

    • safe, effective and less costly
therapeutic approach salpingostomy versus salpingectomy
Therapeutic Approach-salpingostomy versus salpingectomy-
  • Removal of the ectopic pregnancy can be accomplished
    • by resection of the involved fallopian tube with the implanted trophoblastic tissue (salpingectomy)
    • by dissection and removal of only the ectopic pregnancy with tubal conservation (salpingostomy)
therapeutic approach salpingostomy versus salpingectomy47
Therapeutic Approach-salpingostomy versus salpingectomy-

<Reproductive outcomes after salpingostomy and salpngectomy>

  • Yao and Tulandi reviewed the data from 9 studies
    • The follow-up period in these studies ranged from 3months to15years.
    • subsequent intrauterine pregnancy rate was similar in patients who had been treated with salpingostomy and those treated with salpingectomy : 50%
    • the rate of a subsequent ectopic : higher in the salpingostomy group (15% vs 10%)
therapeutic approach salpingostomy versus salpingectomy48
Therapeutic Approach-salpingostomy versus salpingectomy-
  • Other studies
    • a higher intrauterine pregnancy rate in women after salpngostomy

(almost doublethat of salpingectomy),

    • a 2-fold risk of recurrent ectopic after 3years of follow-up

(after salpngostomy)

  • Another recent study
    • a high rate of successful pregnancy after salpingostomy(88%) compared with salpingectomy (66%)
    • with an equal recurrent ectopic rate of about 16% after at least 18months of follow-up and, in some cases, up to 8years posttreatment .
therapeutic approach salpingostomy versus salpingectomy49
Therapeutic Approach-salpingostomy versus salpingectomy-
  • The concern with conservative treatment via salpingostomy is that of the persistence of trophoblast tissue due to incomplete removal from the fallopian tube.

→complicating about 5~20% of cases treated with tubal conservation,

  • It has been reported as being higher in those patients treated with laparoscopy than with laparotomy.

→ very important to document a complete resolution of the ectopic

pregnancy by monitoring the ß-hCG values until they return to zero.

  • Levels that fail to drop, or ones that plateau, indicate a likely persistent ectopic pregnancy that should be treated.
  • Very early gestations, ectopic pregnancies less than 2cm in size, and those with high starting ß-hCG levels are at increased risk of persistence.
therapeutic approach salpingostomy versus salpingectomy50
Therapeutic Approach-salpingostomy versus salpingectomy-
  • In cases of tubal conservation is not indicated
    • if tubal bleeding is encountered that reqiures extensive coagulation to achieve hemostasis, then future tubal function would likely be compromised, and salpingectomy may be the appropriate intervention.
    • Recurrent ectopic pregnancy in a previously incised tube should also be treated with salpingectomy.
therapeutic approach complications of surgery
Therapeutic Approach-Complications of Surgery-
  • Usual operative risk factors as well as those associated with anesthesia.
  • Postop adhesion formation, after laparotomy than laparoscopy

: Postoperative adhesion formation may be reduced by minimizing desiccation and manipulation of pelvic and abdominal structures during surgery, as well as by using barrier agents such as oxidized regernated cellulose(Interceed; Johnson and Johnso Mediacal, New Brunswick, NJ)

follow up reproductive outcome
Follow-up -Reproductive Outcome-
  • Risk of recurrent ectopic pregnancy

after MTX treatment & that after salpingostomy : similar ( about 10%)

  • Tubal patency after MTX treatment is best assessed with hysterosalpingography (HSG)

<Stovall summarized the results of his group’ studies. >

  • Although we do not know the pretreatment tubal patency rates, 58 women of 100 study participants who had received multidose MTX for an ectopic pregnancy underwent HSG and of these, 84.5% had tubal patency and 89.7% had at least one patent tube.
  • After single-dose MTX therapy, 62 patients underwent HSG, with 82.3% showing ipsilateral tubal patency
follow up reproductive outcome53
Follow-up-Reproductive Outcome-

Hafenius et al found

    • Ipsilateral tubal patency was equal in the groups of patients treated with MTX and salpingostomy.
    • much lower overall patency rates, 62% in the MTX group and 66% in the salpingostomy group, compared with previous reports.
  • Reproductive outcome after a previously treated ectopic pregnancy appears to be similar, whether the treatment method had been MTX or conservative surgery.
  • Intrauterine pregnancy rates seen to be comparable in both of these groups, with a possible slightly lower risk of recurrent ectopic seen in the medically treated group.
follow up reproductive outcome54
Follow-up -Reproductive Outcome-
  • Woman who have had a previous ectopic pregnancy should be followed closely during their subsequent pregnancy to ensure its proper site of implantation.
  • However, even among a population of women at increased risk for ectopic, screening them with transvaginal ultrasonography and performing ß-hCG testing when they are asymptomatic does notappear to have much benefit in decreasing morbidity.