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TREATMENT OF IRRITABLE BOWEL SYNDROME BY THE ZONE DIET. Anthony J Dowell MB , BS , MSc , FACS , FRCS(C) Nanaimo Regional General Hospital. IRRITABLE BOWEL SYNDROME. Chronic functional disorder Symptoms well known Cause obscure Treatments unsatisfactory:

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Treatment of irritable bowel syndrome by the zone diet l.jpg

TREATMENT OFIRRITABLE BOWEL SYNDROMEBY THE ZONE DIET

Anthony J Dowell

MB,BS, MSc, FACS, FRCS(C)

Nanaimo Regional General Hospital


Irritable bowel syndrome l.jpg
IRRITABLE BOWEL SYNDROME

  • Chronic functional disorder

  • Symptoms well known

  • Cause obscure

  • Treatments unsatisfactory:

    Prokinetic & antkinetic agents variably effective – suggests motility disorder neuronally or hormonally mediated.


Slide5 l.jpg


Zone diet l.jpg
ZONE DIET

  • Current healthy diets restrict sugar and refined carbohydrate

  • Human gut has not had time to adapt to carbohydrate load since agricultural and industrial revolution

  • Zone diet takes this a step further by using diet to tightly control blood levels of major hormones, principally insulin.

  • Insulin a storage hormone, stores incoming calories as fuel for future use (fat)

  • Zone diet aims to control insulin levels within a tight zone by allowing a fairly constant absorption of low-glycaemic carbohydrate



Zone diet i b s l.jpg
ZONE DIET & I.B.S.

  • PILOT STUDY– 1 year

  • 35 patients

  • All female, 35-75

  • Abd symptoms/pain, clinically IBS

  • TESTS – stepwise approach (Univ of Alberta)

    - minimize, R/O other causes

    constipation/diarrhea predominant pain

  • ZONE DIET - informed consent

    - prospective

    - randomized

    - follow up complete


Results l.jpg
RESULTS

  • Compliance 26/35

  • Unchanged 0/26

  • Improved 10/26

  • Much Better 16/26


Discussion l.jpg
DISCUSSION

  • Numbers small, trend seems very apparent

  • No statistical analysis would be appropriate

  • Real or placebo effect?

  • Original observation

  • No other published literature linking diet or a hormonal mechanism with IBS

  • Crohn’s disease treated with growth hormone

  • Confirmatory studies underway Victoria


Conclusions l.jpg
CONCLUSIONS

  • Symptoms of IBS seem to improve by controlling production of GI hormones, principally insulin, by The Zone Diet.

  • IBS may be hormonally mediated in response to excess dietary sugar & refined carbohydrate.

  • This has not been suggested before.

  • The best treatment for the condition may be cheap and plentiful, and is called food.

  • Clinical trial would seem worthwhile to test this.

  • Fundamental research is planned.