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Physiological Variation in Vascular Reactivity of Breast Tissue over the Menstrual Cycle Demonstrated by Optical Tomogra PowerPoint Presentation
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Physiological Variation in Vascular Reactivity of Breast Tissue over the Menstrual Cycle Demonstrated by Optical Tomography. Katz MS 1 , Hardin RE 1 , Franco NA 1 , Smeraldi AD 2 , Klemer DP 3 , Schmitz CH 3 , Pei Y 3 Graber HL 3 , Barbour RL 3

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Physiological Variation in Vascular Reactivity of Breast Tissue over the Menstrual Cycle Demonstrated by Optical Tomography

Katz MS1, Hardin RE1, Franco NA1, Smeraldi AD2, Klemer DP3, Schmitz CH3, Pei Y3 Graber HL3, Barbour RL3

1Department of Surgery, SUNY Downstate Medical Center

2Department of Vascular Surgery, Staten Island University Hospital

3Department of Pathology, SUNY Downstate Medical Center

Biomedical Optics 2004

Miami Beach, Florida

April 14-17, 2004

optical tomography group
Optical Tomography Group

TechnologyData AnalysisApplications

  • Time series imaging
  • Time multiplexed DC illumination
  • Breast Cancer
  • Limb
  • Brain
  • NEC
  • Fast reconstruction
  • Image enhancement techniques
  • Signal Analysis

Quantitative Functional Imaging

breast cancer
Breast Cancer
  • Cancer is the second most common cause of death. (22%)
  • Breast cancer is the most common type of cancer in females. (211,300).
  • The second most common cause of cancer death in females. (40,110)
  • Most common cause of cancer death in African-American females.
menstrual cycle
Menstrual Cycle
  • Estrogen
  • Breast Enlargement
  • Ductal Growth
  • Progesterone
  • Ductal Maturation
  • Breast Swelling
clinical research
Clinical Research
  • Badwe et al: First study demonstrating correlation between long term survival and phase of menstruation.

Follicular PhaseLuteal Phase

3-12 d. after LMP.

0-2, 13-32 d. after LMP.

54% 10 yr survival 84%

Badwe RA, Gregory WM, Chaudary MA, Ricahrds MA, Bentley AE, Rubens RD, Fentimen IS, “Timing of Surgery During Menstrual Cycle and Survival of Premenopausal Women with Operable Breast Cancer”, Lancet, 1991,337;1:1261-1264.

materials and methods
Materials and Methods
  • 5 Pre-menopausal healthy women were enrolled.
  • Subjects had each breast imaged separately using 25 source x 29 detector array.
  • Each women was measured 3-4 times during the menstrual cycle.
  • Subject were followed for 1-3 months.
  • Subjects were imaged for 1500 consecutive seconds.
  • 500 second baseline (2 time points/second).
  • Repeat Valsalva maneuver of 40mm Hg for 30-40 seconds.
  • 200 second rest period.
  • Data analysis consisted of applying various signal processing routines to the image time series.
criteria for selection of provocation
Criteria for Selection of Provocation
  • Effects entire breast.
  • Repeatable.
  • Serves as a useful discriminator.
pre menopausal
Pre-Menopausal

Day 1

Day 12

Day 19

Day 28

Oxy-Hemoglobin

Day 1

Day 12

Day 19

Day 28

Deoxy-Hemoglobin

pre menopausal12
Pre-Menopausal

Day 1

Day 12

Day 19

Day 28

Oxy-Hemoglobin

Subject #1

Day 5

Day 12

Day 17

Day 26

Subject #2

pre menopausal13
Pre-Menopausal

Day 1

Day 12

Day 19

Day 28

Subject #1

Deoxy-Hemoglobin

Day 5

Day 12

Day 17

Day 26

Subject #2

post menopausal
Post Menopausal

Day 1

Day 8

Day 14

Day 26

Oxy-Hemoglobin

Deoxy-Hemoglobin

percentage of variance16
Percentage of Variance

Day 1

Day 12

Day 19

Day 28

Oxy-Hemoglobin

Oxygenated Hemoglobin

phase 1
Phase 1

Day 1

Day 12

Day 19

Day 28

Oxy-Hemoglobin

1-

0-

1-

0-

1-

0-

1-

0-

% of SD Pairs

% of SD Pairs

% of SD Pairs

0 50 100

% of SD Pairs

phase 3
Phase 3

Day 1

Day 12

Day 19

Day 28

Oxy-Hemoglobin

Deoxy-Hemoglobin

Oxy-Hemoglobin

Red-Hemoglobin

1-

0-

1-

0-

phase 4
Phase 4

Day 1

Day 12

Day 19

Day 28

Oxy-Hemoglobin

Deoxy-Hemoglobin

Oxy Hemoglobin

Red Hemoglobin

1-

0-

1-

0-

spatial map of onset of maximal response
Spatial Map of Onset of Maximal Response

Day12

Day1

Right Breast P1

Day19

Left Breast P1

Right Breast N2

Left Breast N2

conclusions
Conclusions
  • Vascular response of breast to the Valsalva maneuver is mainly coherent and repeatable.
  • Response profile to Valsalva maneuver varies over the menstrual cycle.
  • Largest variation in profile is seen with deoxy-hemoglobin whereas largest variation in rate is seen with oxy-hemoglobin.