Neurobiology and Pharmacological Treatment of Pathological Gambling . Jon E. Grant, JD, MD, MPH Associate Professor University of Minnesota School of Medicine Minneapolis, MN. Disclosure Information. I have the following financial relationships to disclose:
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Jon E. Grant, JD, MD, MPH
University of Minnesota
School of Medicine
Grant et al., Am J Psychiatry, Nov. 2005
R tegmental area and prefrontal cortex and has direct access to and influence on motor output structures.
DecreasesLeft vmPFC Implicated During Stroop Performance In ICDs
PG(Potenza et al, 2003, Am J Psychiatry)
Control(Potenza et al, 2003, Am J Psychiatry)
PG - Control(Potenza et al,2003, Am J Psychiatry)
Bipolar - Cont(Blumberg et al, 2003, Arch Gen Psychiatry)
Source: Look Magazine, March, 1963 tegmental area and prefrontal cortex and has direct access to and influence on motor output structures.
Persistent and recurrent maladaptive gambling behavior as indicated by five (or more) of the following:
including major depression
and anxiety disorders 40-60%
Lifetime and Current ICDs in 293 Adults with Obsessive Compulsive Disorder
Grant et al., J Psychiatr Res, in press
PG Y-BOCS Gambling Behavior Score
Rx response (N = 10)
Mean PG Y-BOCS Score
Hollander et al, Am J Psychiatry 1998;155:1781-1783
59% response rate in the paroxetine group Compulsive Disorder
49% rate in the placebo group
45 completers (Grant et al. 2003)
Look at family history, comorbidities
Lexapro Treatment of Anxious Gamblers Compulsive Disorder
Mean PG Y-BOCS Score
Hollander et al, 2002
Acknowledgments thereby reducing synaptic release of glutamate and dopamine.
Funding: NIMH, NARSAD, GlaxoSmithKline, BioTie, Oy Contral, Forest
Collaborators: SW Kim, Marc Potenza, Rani Desai, Carlos Blanco, Eric Hollander, Matt Kushner, Dorothy Hatsukami