Cannabis • Pot, herb, weed, grass, widow, ganja, hash, dank, mota/moto, hierba, pasto, etc.
THC Concentration is Different in Various Preparations of Marijuana • “Ordinary” marijuana ~3% • Sinsemilla (seedless female plant) -7.5% average, up to 24% • Hashish (cannabis buds)- 3.6% average, up to 28% • Hash oil (non-polar extract of marijuana or hashish)- 16% average, up to 43%
Cell Biology: Marijuana is a drug that binds receptors on cell membranes marijuana Binding of the drug to the receptor causes changes within the cell receptor Structural changes Functional changes cell
Effects of Smoking Cannabis • Euphoria followed by tiredness, passivity • Eye reddening (a hallmark) • Increased heart rate, dry mouth and eyes • Dizziness • Defects in short-term memory and cognition • Lung Disease • Hormone abnormalities (gynecomastia)
Pathway Of Marijuana In The Body lips/mouth inhale marijuana lungs bloodstream brain other organs/ tissues heart
Normal Lungs and Physiology Lungs are the site of gas exchange: oxygen enters blood and carbon dioxide leaves blood
Marijuana Damages the Lungs • Marijuana contains tar, carbon monoxide, and • carcinogens that damage the lungs • Marijuana smoke contains 50 to 70% more toxic chemicals • than tobacco smoke • Marijuana use increases the risk of lung disease
Diseased Lung Healthy Lung
The Heart I Right side of heart pumps blood to the lung where it picks up oxygen; left side of heart pumps blood to the entire body.
Marijuana Harms Heart Function • Increases heart rate (tachycardia) • Vessels dilate (enlarge), disturbing heart function
Marijuana Affects the Brain • Marijuana Acts On : • Cerebellum (coordination) • Basal ganglia (motor) • Hippocampus (memory)
Marijuana Can Cause Brain Damage • Loss of short-term memory • Cognitive deficits • Apathy
Altered hormone levels Enlarged breasts in males (gynecomastia) Hormone Problems are Associated with Marijuana Use
Medical Marijuana • THC is available by prescription (Marinol) • Antiemetic (prevents vomiting) • Glaucoma • Muscle relaxant
Contact Information Adolescent Counseling Services http://www.acs-teens.org 650-424-0852 or 650-424-9853 (Fax) 4000 Middlefield Road Rm FH, Palo Alto, CA 94303 Stanford Chapter of Student National Medical Association http://snma.stanford.edu Aileen Green firstname.lastname@example.org ChaRandle Jordan email@example.com 650-497-9287
References for Images http://www.oconeelaw.com/.../ marijuana/blunt.jpg http://www.netdoctor.co.uk/focus/heart/index.shtml cannabis.gif (chemical structure of THC) http://www.toxlab.co.uk/cannabis.htm man.gif (smoking stick figure) http://www.colostate.edu/Depts/ NatSci/html/Major8.html Lungs.jpg (schematic of lung) http://www.alpha1.org.uk/COPD/ Illness/the_lung.htm Lung Blood -air barrier copy W... (schematic of gas exchange in alveolus) http://www.education.vetmed.vt.edu/.../EXAMPLES/ exgasbarrierdiag.htm clean_lung_hr.jpg (healthy lung) http://www.lungusa.org/learn/ art/clean_lung_hr.jpg diseased_lung.jpg (diseased lung) http://www.lungcancer.org/images/patients/ lungs/diseased_lung.jpg bc47.jpg (sagittal brain) http://www.cns.georgetown.edu/ medneuro/lab1/ brain.jpg (side view of head and brain) http://www.bbc.co.uk/schools/ parents/