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Quad-Rat Vitals Monitor. Advisor: Paul Thompson Client: Dr. Alex Converse. Overview. PET Imaging Requirements Existing Devices Previous Semester’s Work Pulse Oximeter Probe Design Options LabVIEW Interface Design Options Where do we go from here? Acknowledgments. PET Imaging of Rats.

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quad rat vitals monitor

Quad-Rat Vitals Monitor

Advisor: Paul Thompson

Client: Dr. Alex Converse

  • PET Imaging
  • Requirements
  • Existing Devices
  • Previous Semester’s Work
  • Pulse Oximeter Probe Design Options
  • LabVIEW Interface Design Options
  • Where do we go from here?
  • Acknowledgments
pet imaging of rats
PET Imaging of Rats
  • Positron emission tomography (PET) scans to monitor location of tracers in rats
  • Client scans four anesthetized rats at a time
    • Needs to monitor the rats’ vitals



requirements quads vitals monitor
Requirements: Quads Vitals Monitor
  • Client needs to simultaneously monitor four rats
    • SpO2levels, accuracy of ±2%
    • Heart rates up to 500 beats per minute
    • Respiratory rates of 20 to 30 breaths per minute
    • Rectal temperatures of 93 - 100° F
  • Non-invasive probes and user-friendly interface
existing devices
Existing Devices
  • Existing devices:
    • Client currently uses rudimentary devices to monitor vitals
    • Available: Pulse oximeter for mice and rats
      • Over $7000, one rat at a time


previous semester s work
Previous Semester’s Work
  • Developed circuit for detecting breathing rate using force sensing resistor
  • Designed and calibrated thermistor to detect temperature
  • Designed Graphical User Interface (GUI) in LabVIEW displaying breathing rate and temperature
  • Attempted to reverse engineer existing Pulse Oximeter

Force sensing resistor

LabVIEW interface

general probe requirements
General Probe Requirements
  • Applicable for rats of varying size
  • Reusable
  • Sufficient blocking of ambient light
  • Compatible LED and Photodiode


foot clip
Foot Clip
  • Pros:
    • Similar to current device
    • Easy to reposition
    • Positioned far from the head
  • Cons:
    • Can displace easily
    • Risk of LED/Photodiode misalignment
    • Potential to apply excessive pressure
foot wrap
Foot Wrap
  • Pros:
    • No displacement once attached
    • Alignment of LED/Photodiode maintained throughout testing
  • Cons:
    • Not adjustable
    • More involved cleaning process
tail clip
Tail Clip
  • Pros:
    • Easy to attach
      • No confusion over placement location
    • Adjustable
  • Cons:
    • May interfere with catheter in tail
    • Potential to apply excessive pressure
four corners with buttons13
Four Corners with Buttons
  • Pros:
    • Logical layout
    • Important information visible
  • Cons:
    • Extra clicking
    • History graphs incomparable
    • Less robust

A sample quarter of the final display

tab interface
Tab Interface
  • Pros:
    • Uncluttered interface
    • Easy to program
  • Cons:
    • Inefficient
    • Data hard to compare

Full display

four corners with histories16
Four Corners with Histories
  • Pros:
    • All data on one screen
    • Easy to compare trends
  • Cons:
    • Cluttered interface
    • Tiny on small screen

A sample quarter of the final display

where do we go from here
Where do we go from here?
  • Finish LabVIEW GUI
    • Determine how data will be collected from Pulse Oximeter
  • Design pulse-ox probe to fit rat’s hind paw
    • Integrate with signal received from Graduate Students’ circuit
  • Print circuit boards
  • Fabricate housing apparatus
  • Professor Paul Thompson
  • Dr. Alex Converse
  • Amit Nimunkar
  • Tim Balgemann
  • Liz Ahlers
  • Nate Werbeckes