Protein Calorie Malnutrition . Protein-Calorie Malnutrition . PCM affects ~ 1 billion individuals world-wide In US, 30-50% of patients will be malnourished at admission to hospital 69% will have a decline in nutrition status during hospitalization
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(I) Exogenous; (II) Glycogen, Liver gluconeogenesis;
(III) Liver gluconeogenesis, Glycogen;
(IV & V)Liver and Kidney gluconeogenesis
Major fuel of brain:
(I) - (III) Glucose; (IV) Glucose, ketone bodies;
(V) Ketone bodies, glucose
1.Maintain glucose homeostasis and conserve glucose pool.
2. Preserve structural and functional lipids and proteins
3. Preserve the organism
Preferential visceral uptake of AA released by peripheral tissue
Severe Energy Depletion: Loss of Skinfold Thickness