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Healthy and Harmful Halogens Iodine and Fluoride. Conference Be Healthy, Wealthy, and Wise Center for Libertarian Studies Foster City, CA December 2, 2006 Donald W. Miller, Jr., M.D . Professor of Surgery Division of Cardiothoracic Surgery

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healthy and harmful halogens iodine and fluoride
Healthy and Harmful HalogensIodine and Fluoride
  • Conference
  • Be Healthy, Wealthy, and Wise
  • Center for Libertarian Studies
  • Foster City, CA
  • December 2, 2006
      • Donald W. Miller, Jr., M.D.
      • Professor of Surgery
      • Division of Cardiothoracic Surgery
      • University of Washington School of Medicine

Atomic Wt. Discovered

Fluorine 19 1886

Chlorine 35 1809

Bromine 80 1826

Iodine 127 1811

Astatine 210 1940

halogens in war
Halogens in War



elements that compose the human body
Elements that Compose the Human Body


Periodic Table of Elements


fluoride in dr strangelove
Fluoride in Dr. Strangelove

“Have you ever seen a commie drink a glass of water?”

Capt. Jack D. Ripper

lead fluoride and arsenic
Lead, Fluoride and Arsenic

Toxicity Maximum Contaminant Levels

manifestations of fluoride poisoning
Manifestations of Fluoride Poisoning
  • Skeletal Fluorosis
    • Arthritis
    • Osteoporosis/Fracture
    • Crippling deformities
  • Neurotoxicity
    • Abnormal brain development
    • Alzheimer’s disease
  • Hypothyroidism
manifestations of fluoride poisoning14
Manifestations of Fluoride Poisoning
  • Increases risk for cancer
    • Osteosarcoma
    • Hepatocholangiocarcinoma
  • Early onset of puberty
    • Due to impaired melatonin production
  • Reduced male fertility
water filters that remove fluoride
Water Filters that Remove Fluoride

Reverse Osmosis Distiller

water fluoridation in u s
Water Fluoridation in U.S.

Goal (Objective 21-9): Increase proportion of U.S. population served by fluoridated community water systems to 75 percent

actions of triiodothyronine t 3
Actions of Triiodothyronine (T3)
  • Regulate cellular oxidation
    • Calorigenesis
    • Thermoregulation
    • Intermediary Metabolism
  • Necessary for protein synthesis
  • Promotes
    • Nitrogen retention
    • Glycogenolysis
    • Intestinal absorption of glucose and galactose
    • Lipolysis
    • Uptake of glucose by adipocytes

Iodine Deficiency Disorders

Goiter Mental Retardation


reference daily intake rdi for iodine
Reference Daily Intake(RDI) for Iodine

According to the AMA, NIH National Research Council, Joint UN FAO/WHO Expert Committee on Food Additives, and the EU IPCS

RDI: 100-150 μg/day

worldwide iodine nutrition
Worldwide Iodine Nutrition

Median urinary iodine concentration of 100-199 ug/L with corresponding approximate iodine intake 150-299 ug/day

International Council for the Control of Iodine Deficiency Disorders.

Current IDD Status Database, 2003

iodine intake in japan
Iodine Intake in Japan

Iodine Intake 1950-1963:

13.8 mg/per capita/day (average 4.5 gm seaweed a day. Measured Iodine content 0.3mg/gm)

Seaweed consumption in 2001: 14.6 gm (dry weight)

Iodine Intake 2001: 43.8 mg If Iodine content the same (was not measured)

Nutrition in Japan, 1964. Nutrition Section, Bureau of Public Health, Ministry of Health and Welfare, Tokyo, Japan, March 1965

iodine intake in the united states

NHANES I, 1971-741

NHANES III, 1988-911










1Hollowell, JE et al. Iodine nutrition in the United States. Trends and public health implications: Iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971-74 and 1988-94). J Clin Endocrinol Metab 83:3401-3408. 1998.

Iodine Intake in the United States

Urinary iodine levels (µg/L) in

the United States, age 6-74

Current Average Daily Intake of Iodine:

240 µg (0.24 mg)

Iodine Intake in 1970s: 480 µg (0.48 mg)




health comparisons united states and japan
Health Comparisons: United States and Japan

United States Japan

Incidence of Breast Highest in World Lowest


Life Expectancy77.85 years 81.25 years

(48th/226 countries) (No. 6)

Infant Mortality Rate 7.0 3.5

(deaths under age 1 per (Lowest in World)

1,000 live births)

the earth s 3 rd atmosphere from 2 2 ga
The Earth’s 3rd Atmosphere, from 2.2 Ga


Level in



4.6 3.6 2.6 1.6 0.6

Billion Years Ago

  • Photosynthesis first done by Cyanobacteria:
    • 6CO2 + 6H2O → C 6H12O6 + 6O2
  • Cyanobacteria are also the first life forms to tolerate and use……………………...


iodine as an antioxidant
Iodine as an Antioxidant

Reactive Oxygen Species

I-+ H2O2 HIO + OH-

HIO + I- + H+I2 + H2O

Kupper FC, et al. Iodine uptake in Laminariales involves extracellular, haloperoxidase-mediated oxidation of iodide. Planta 1998;207:163-171.

function of iodine in humans and other animals
Function of Iodine in Humans and Other Animals

Thyroidal -- Organic

  • A Component of Thyroxine and T3

Extrathyroidal -- Inorganic

  • An Antioxidant
  • Triggers Apoptosis
  • Other
    • Detoxify chemicals and biological toxins
    • Anti-allergic, coat external proteins rendering them non allergic
    • Suppess auto-immunity
    • Strengthen immune system
    • Provide antisepsis in the stomach

Iodine-Induced Apoptosis in Lung Cancer

Iodine Sensitive Lung Cancer Cells Parent (unmodified) Lung Cancer Cells

Zhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis in Genetically Modified Lung Cancer Cells. Cancer Research 2003;63:5065-5072


Effect of Iodine on Tumor Growth in Mice

Genetically Modified Tumor Xenograft Controls

Genetically Modified Tumor Xenograft with Iodine

Zhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis in Genetically Modified Lung Cancer Cells. Cancer Research 2003;63:5065-5072

organs with iodine concentrating ability via the sodium iodine symporter pump
Organs with Iodine Concentrating AbilityVia the Sodium/Iodine Symporter Pump

Stomach Mucosa

Mammary Glands

Salivary Glands




Choroid Plexus

Articular, Arterial, and Skeletal Systems

125I total-body scintiscans

30 min 6 hr 20 hr

Venturi S, et al. Role of Iodine in Evolution and Carcinogenesis of Thyroid, Breast and Stomach. Adv Clin Path 2000;4:11-17.

the real truth on iodine dose related benefits
In microgram (μg) amounts:

In milligram (mg) amounts:

In gram (g) amounts:

For thyroid hormone

Achieve optimal health

Prevent (and treat) fibrocystic disease of the breast

Prevent cancer

Civil Defense

Treat multiple diseases: dermatologic, pulmonary, cardiovascular, fungal

The Real Truth on IodineDose-Related Benefits
different kinds of iodine
Different Kinds of Iodine
  • Inorganic, Nonradioactive (127I)
    • KI, SSKI, Lugol’s Solution, Iodoral,
    • Tincture of Iodine, Povidone-Iodine)
  • Organic
    • Endogenous
      • Thyroid hormones
    • Synthetic
      • Amiodarone
      • Radiocontrast media
        • Iopanoic acid, Meglumine Iotroxate, Propyliodone, etc.
  • (Inorganic) Radioactive Isotopes
forms of inorganic nonradioactive iodine
Forms of Inorganic, Nonradioactive Iodine
  • KI (Potassium Iodide)
    • A 130 mg tablet contains 100 mg of iodide
  • SSKI (Saturated Solution of Potassium Iodide)
    • 38 mg/drop iodide (760 mg/ml)
      • 19 mg/drop in Tahoma Clinic’s SSKI Tri-Quench
  • Lugol’s Solution -- 5% iodine (I2) and 10% KI
    • 6.5 mg/drop blend of iodine and iodide (130 mg/ml)
  • Iodoral -- 5% iodine and 10% KI
    • One tablet = 12.5 mg blend of iodine and iodide
iodine poisoning
Iodine Poisoning

Ingested 15 gmof Iodine – 100,000 x the RDA of 0.00015 gm (150 μg)

Serum Iodide level was 2,950 ug/dL (normal is 3.5 μg/dL with daily intake of 150 ug Iodine)

Salivary Iodide Level 60,000 ug/dL

(normal 105 μg/dL)

iodine in dermatology
Iodine in Dermatology


Sterling JB, Heymann WR. Potassium Iodide

In Dermatology: A 19th Century Drug for the 21st Century—Uses, Pharmacology, Adverse Effects, and Contraindications. J Am Acad Dermatol 2000;43:691-697.





fibrocystic breast disease
Fibrocystic Breast Disease


Fibrous tissue

Epithelial and apocrine hyperplasia

Elemental Iodine, I2, more effective than Iodide, I-

Ghent WR, Eskin BA, Low DA, Hill LP. Iodine Replacement in Fibrocystic Disease of the Breast. Can J Surg 1993;36:453-460.

iodine prevents breast cancer
Iodine Prevents Breast Cancer

Animal Studies

Reduces incidence in rats given carcinogens

Human Studies

Kills cancer cells grown in vitro

Absorbed by cancer-prone ductal epithelium

Epidemiological Studies

Increased incidence with goiter

Lower incidence in people who eat seaweed and fish

the iodine project
The Iodine Project

Hypothesis: Whole body sufficiency of iodine requires mg (12.5 mg), not μg (150 μg ) daily amounts

Principle Investigators

Guy Abraham MD, 1997: Optimox Corp., Torrance, CA

Jorge Flechas MD, 2000 (1,000 pts.): Flechas Family Practice, Hendersonville, NC

David Brownstein MD, 2003 (3,000 pts.): Center for Holistic Medicine, West Bloomfield, MI

Iodine Loading Test

Take 50 mg iodine, urine collected for 24 hours

Less than 90 % excretion indicates iodine insufficiency

health benefits of mg dose iodine at 100x the rdi
Health Benefits of mg-Dose Iodine at 100x the RDI
  • Feel Healthier
    • Sense of Well-Being
    • Lifting of Brain Fog
    • Increased Energy –

Achieve More in Less Time

  • Feel Warmer in Cold


  • Need Less Sleep
  • Regular Bowel Movements
  • Improved Skin Complexion
  • Strengthens Immune System
  • Prevents Cancer
  • Blocks 131I Absorption from Radioactive Fallout