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Local Anesthetics- History. 1860 - cocaine isolated from erythroxylum cocaKoller - 1884 uses cocaine for topical anesthesiaHalsted - 1885 performs peripheral nerve block with localBier - 1899 first spinal anesthetic . Local Anesthetics - Definition. A substance which reversibly inhibits nerve conduction when applied directly to tissues at non-toxic concentrations.

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