Recent research stories silent version
Download
1 / 42

- PowerPoint PPT Presentation


  • 379 Views
  • Updated On :

“Recent Research Stories” (Silent Version) “Recent Research Stories” (Silent Version) For sound, please feel free to come see me. Cheers, Geoff

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about '' - JasminFlorian


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

Recent research stories silent version2 l.jpg
“Recent Research Stories” (Silent Version)

For sound, please feel free to come see me.

Cheers,

Geoff


Previous graduates from the rosenfeld laboratory l.jpg
Previous Graduates from the Rosenfeld Laboratory

Susan Amara

Rouping Chen

Bryan Crenshaw

Daniel Drolet

Glen Evans

Xi He

Ola Hermanson

Jeff Holloway

Holly Ingraham

Kristen Jepsen

Michael Kapiloff

Chrissa Kioussi

Peng Li

Steve Lipkin

Sergio Lira

Professor, Vollum Institute, Investigator, HHMI

Staff Scientist, Celera Genomics

Assoc. Professor, University of Pennsylvania

Assoc. Research Director, NeXagen Inc.

Professor, Univ of Texas, Southwestern, School of Medicine

Asst. Professor, Harvard Medical School

Assist. Professor, Karolinska Institute, Stockholm, Sweden

Staff Scientist, Unigen Pharmaceuticals Inc.

Professor, UC San Francisco

Assoc. Research Scientist, UC San Diego

Assist. Professor, Univ of Oregon, School of Medicine

Assist. Professor, Oregon State University

Professor, The Singapore Institute of Biology

Assist. Professor, UC Irvine, School of Medicine

Adjunct Professor, Mt. Sinai School of Medicine

3


Previous graduates from the rosenfeld laboratory continued l.jpg
Previous Graduates from the Rosenfeld Laboratory(continued)

Assoc. Research Scientist, UC San Diego

Assoc. Professor, Univ of Oregon, School of Medicine

Assist. Professor, Harvard Medical School

Assist. Professor, University of Massachusetts

Assoc. Project Scientist, UC San Francisco

Assist. Project Scientist, UC San Diego

Assist. Professor, Stanford University

Postdoctoral Fellow, University of Washington

Project Scientist, Illumina

Professor, UC Irvine, School of Medicine

Assist. Professor, University of Massachusetts

Robert McEvilly

Geoffrey Murdoch

Anders Näär

Franco Rodrigo

Marcus Schonneman

Kathleen Scully

Mark Sornson

Daniel Szeto

Jo Yeakley

Marion Waterman

Lan Xu

4


Slide5 l.jpg

5


Biochemical identification of the nuclear receptor corepressor n cor l.jpg
Biochemical Identification of the Nuclear Receptor Corepressor (N-CoR)

6



Identification of the minimal corepressor nr interaction motif l.jpg
Identification of the Minimal Corepressor/NR Interaction Motif

8








Transient signaling gradients and induced transcription factors in pituitary development l.jpg
Transient Signaling Gradients and InducedTranscription Factors in Pituitary Development

15





Dna binding independent functions of pit 1 restrict gonadotrope gene expression out of thyrotropes l.jpg
DNA Binding-independent Functions of Pit-1 Restrict Gonadotrope Gene Expression Out of Thyrotropes

19


Three pit 1 cell types express distinct hormone encoding gene targets l.jpg
Three Pit-1+ Cell Types Express Distinct Gonadotrope Gene Expression Out of ThyrotropesHormone-encoding Gene Targets

20


Co crystal structure of pit 1 pou domains on gh and prl dna response elements l.jpg
Co-crystal Structure of Pit-1 POU Domains Gonadotrope Gene Expression Out of Thyrotropeson GH and Prl DNA Response Elements

21


Combinatorial recruitment of a corepressor complex in long term active repression of the gh gene l.jpg
Combinatorial Recruitment of a Corepressor Complex in Gonadotrope Gene Expression Out of ThyrotropesLong-term Active Repression of the GH Gene

22


Drosophila sine oculis mutations l.jpg

toy Gonadotrope Gene Expression Out of Thyrotropes

ey/Pax6

so/Six

optx/six6

eya/Eya

dac/Dach

SD

HD

Six

Drosophila sine oculis Mutations

Zipursky et al. Neuron Vol. 12, 977-996 1994

23


Six6 retinal progenitor cells has reduced proliferation potential l.jpg
Six6-/- Retinal Progenitor Gonadotrope Gene Expression Out of ThyrotropesCells Has Reduced Proliferation Potential

24


Six6 dach2 are required for precise regulation of rpc proliferation l.jpg
Six6/Dach2 are Required for Gonadotrope Gene Expression Out of ThyrotropesPrecise Regulation of RPC Proliferation

25


Phenotype of six1 mice l.jpg
Phenotype of Six1-/- Mice Gonadotrope Gene Expression Out of Thyrotropes

26


Phenotype of six1 mice27 l.jpg
Phenotype of Six1-/- Mice Gonadotrope Gene Expression Out of Thyrotropes

27


The eya family are functional protein phosphatases l.jpg
The Eya Family are Functional Protein Phosphatases Gonadotrope Gene Expression Out of Thyrotropes

28


Model of eya phosphatase actions in six1 dach eya regulation of organogenesis l.jpg
Model of Eya Phosphatase Actions in Gonadotrope Gene Expression Out of ThyrotropesSix1/Dach/Eya Regulation of Organogenesis

29


Pitx2 rieg otlx2 arp1 l.jpg
Pitx2 / RIEG / Otlx2 / ARP1 Gonadotrope Gene Expression Out of Thyrotropes

30


Phenotype of pitx2 gene deleted mice l.jpg

-/- Gonadotrope Gene Expression Out of Thyrotropes

+/+

pituitary

-/-

+/+

+/+

-/-

tooth

+/+

-/-

Phenotype of Pitx2 Gene-deleted Mice

Visceral and Axial Turning

Abnormalities

lung

Right Pulmonary Isomerism

Organ Determination and Proliferation

31


Slide32 l.jpg

32 Gonadotrope Gene Expression Out of Thyrotropes


Il 1 b dependent export of n cor tab2 hdac3 l.jpg
IL-1 Gonadotrope Gene Expression Out of Thyrotropesb-dependent Export of N-CoR/TAB2/HDAC3

33


Il 1 dependent kai1 gene induction based on a corepressor coactivator exchange l.jpg
IL-1-dependent KAI1 Gene Induction Based on a Corepressor/Coactivator Exchange

34


Models of kai1 activation by inflammation and disease l.jpg
Models of KAI1 Activation by Inflammation and Disease Corepressor/Coactivator Exchange

35


Secretase dependent cleavage of app l.jpg
Secretase-dependent Cleavage of APP Corepressor/Coactivator Exchange

36


App interactions with potential signalling molecules l.jpg
APP Interactions with Potential Signalling Molecules Corepressor/Coactivator Exchange

37


Presenilin dependent generation of transcriptional coactivators l.jpg
Presenilin-dependent Generation of Corepressor/Coactivator ExchangeTranscriptional Coactivators

38


Potential rest regulated gene targets l.jpg
Potential REST-Regulated Gene Targets Corepressor/Coactivator Exchange

39


Corest dependent silencing of the rch39q21 36 interval l.jpg
CoREST-dependent Silencing of the rCh39q21-36 Interval Corepressor/Coactivator Exchange

40


Model of corest dependent silencing of a chromosomal interval l.jpg
Model of CoREST-dependent Silencing Corepressor/Coactivator Exchangeof a Chromosomal Interval

41


The end recent research stories by geoff rosenfeld l.jpg
“THE END” Corepressor/Coactivator ExchangeRecent Research StoriesbyGeoff Rosenfeld


ad