“Recent Research Stories” (Silent Version) - PowerPoint PPT Presentation

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  1. “Recent Research Stories” (Silent Version)

  2. “Recent Research Stories” (Silent Version) For sound, please feel free to come see me. Cheers, Geoff

  3. Previous Graduates from the Rosenfeld Laboratory Susan Amara Rouping Chen Bryan Crenshaw Daniel Drolet Glen Evans Xi He Ola Hermanson Jeff Holloway Holly Ingraham Kristen Jepsen Michael Kapiloff Chrissa Kioussi Peng Li Steve Lipkin Sergio Lira Professor, Vollum Institute, Investigator, HHMI Staff Scientist, Celera Genomics Assoc. Professor, University of Pennsylvania Assoc. Research Director, NeXagen Inc. Professor, Univ of Texas, Southwestern, School of Medicine Asst. Professor, Harvard Medical School Assist. Professor, Karolinska Institute, Stockholm, Sweden Staff Scientist, Unigen Pharmaceuticals Inc. Professor, UC San Francisco Assoc. Research Scientist, UC San Diego Assist. Professor, Univ of Oregon, School of Medicine Assist. Professor, Oregon State University Professor, The Singapore Institute of Biology Assist. Professor, UC Irvine, School of Medicine Adjunct Professor, Mt. Sinai School of Medicine 3

  4. Previous Graduates from the Rosenfeld Laboratory(continued) Assoc. Research Scientist, UC San Diego Assoc. Professor, Univ of Oregon, School of Medicine Assist. Professor, Harvard Medical School Assist. Professor, University of Massachusetts Assoc. Project Scientist, UC San Francisco Assist. Project Scientist, UC San Diego Assist. Professor, Stanford University Postdoctoral Fellow, University of Washington Project Scientist, Illumina Professor, UC Irvine, School of Medicine Assist. Professor, University of Massachusetts Robert McEvilly Geoffrey Murdoch Anders Näär Franco Rodrigo Marcus Schonneman Kathleen Scully Mark Sornson Daniel Szeto Jo Yeakley Marion Waterman Lan Xu 4

  5. 5

  6. Biochemical Identification of the Nuclear Receptor Corepressor (N-CoR) 6

  7. LXXLL Motifs in Coactivator Function 7

  8. Identification of the Minimal Corepressor/NR Interaction Motif 8

  9. Biological Roles of N-CoR (Proliferation/Transformation) 9

  10. N-CoR is Required for NSC Maintenance and Proliferation 10

  11. N-CoR is Required to Maintain the Neural Stem Cell State 11

  12. Hypothalamic Pituitary Axis 12

  13. 13

  14. 14

  15. Transient Signaling Gradients and InducedTranscription Factors in Pituitary Development 15

  16. Heritable Defects in Mouse Pituitary Development 16

  17. Pit-1 Determines Three Anterior Pituitary Cell Types 17

  18. Phenotype Variation in Prop-1 Disease Alleles 18

  19. DNA Binding-independent Functions of Pit-1 Restrict Gonadotrope Gene Expression Out of Thyrotropes 19

  20. Three Pit-1+ Cell Types Express DistinctHormone-encoding Gene Targets 20

  21. Co-crystal Structure of Pit-1 POU Domainson GH and Prl DNA Response Elements 21

  22. Combinatorial Recruitment of a Corepressor Complex inLong-term Active Repression of the GH Gene 22

  23. toy ey/Pax6 so/Six optx/six6 eya/Eya dac/Dach SD HD Six Drosophila sine oculis Mutations Zipursky et al. Neuron Vol. 12, 977-996 1994 23

  24. Six6-/- Retinal ProgenitorCells Has Reduced Proliferation Potential 24

  25. Six6/Dach2 are Required forPrecise Regulation of RPC Proliferation 25

  26. Phenotype of Six1-/- Mice 26

  27. Phenotype of Six1-/- Mice 27

  28. The Eya Family are Functional Protein Phosphatases 28

  29. Model of Eya Phosphatase Actions inSix1/Dach/Eya Regulation of Organogenesis 29

  30. Pitx2 / RIEG / Otlx2 / ARP1 30

  31. -/- +/+ pituitary -/- +/+ +/+ -/- tooth +/+ -/- Phenotype of Pitx2 Gene-deleted Mice Visceral and Axial Turning Abnormalities lung Right Pulmonary Isomerism Organ Determination and Proliferation 31

  32. 32

  33. IL-1b-dependent Export of N-CoR/TAB2/HDAC3 33

  34. IL-1-dependent KAI1 Gene Induction Based on a Corepressor/Coactivator Exchange 34

  35. Models of KAI1 Activation by Inflammation and Disease 35

  36. Secretase-dependent Cleavage of APP 36

  37. APP Interactions with Potential Signalling Molecules 37

  38. Presenilin-dependent Generation ofTranscriptional Coactivators 38

  39. Potential REST-Regulated Gene Targets 39

  40. CoREST-dependent Silencing of the rCh39q21-36 Interval 40

  41. Model of CoREST-dependent Silencingof a Chromosomal Interval 41

  42. “THE END”Recent Research StoriesbyGeoff Rosenfeld