Multiple Sclerosis. Meaning “many scars”. Emily Harry Dr. Buynak Medicinal Chemistry 5398 Southern Methodist University April 23, 2009. Overview:. What is it? Symptoms Diagnosis Types Trying to understand MS Blood Brain Barrier Mineral abnormalities What are the causes?
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Meaning “many scars”
Medicinal Chemistry 5398
Southern Methodist University
April 23, 2009
Immune system crosses the BBB and attacks the myelin sheath on neuronal cells.
Glatiramer acetate consists of random polymers of 4 amino acids, designed to mimic myelin basic protein, an important component of CNS myelin. Believed to work by activating anti-inflammatory regulatory T cells, which then migrate into the CNS to inhibit local immune rxns.
Immunomodulator Interferon-ß protein in human cells