Influenza A H1 N1. Prepared by Dr Alissar Rady, WHO Lebanon. Influenza Virus Types A and B. Circulating Influenza Strains and Pandemics in The 20 th Century. 1968: “Hong Kong Flu”. 1918: “Spanish Flu”. 1957: “Asian Flu”. 20-40 million deaths. 1-4 million deaths.
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Dr Alissar Rady, WHO Lebanon
1968: “Hong Kong Flu”
1918: “Spanish Flu”
1957: “Asian Flu”
20-40 million deaths
1-4 million deaths
1920 1940 1960 1980 2000
Appear in the human population rarely and unpredictably
Human population lacks any immunity
All age groups, including healthy young adults
A public health problem each year
Usually some immunity built up from previous exposures to the same subtype
Infants and elderly most at risk
A new influenza virus emerges to which the general population has little/no immunity
The new virus must be able to replicate in humans and cause disease
The new virus must be efficiently transmitted from one human to another
Influenza A (H1N1)
Reassortment in humans
Reassortment in pigs
Pandemic Influenza Virus
fall on people
surfaces bed clothes
Courtesy of CDC
Source: Rosie Sokas, MD MOH UIL at Chicago
Treatment is 75 mg twice a day for 5 days.
Prophylaxis is 75 mg once a day for 7 days after last exposure.
High risk exposure (household contacts)
Moderate risk (unprotected very close exposure to sick animals; HCW with unprotected exposure to patients)
Low risk exposure: no need for prophylaxis unless activation of exceptional measures.