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The Science and Ethics of Reproductive Cloning: Introduction to the Science California Science Center April 15, 2006 PowerPoint Presentation
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The Science and Ethics of Reproductive Cloning: Introduction to the Science California Science Center April 15, 2006 Edward RB McCabe, MD, PhD Physician-in-Chief, Mattel Children’s Hospital at UCLA Co-Director, UCLA Center for Society and Genetics www.socgen.ucla.edu

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The Science and Ethics of Reproductive Cloning:Introduction to the ScienceCalifornia Science CenterApril 15, 2006

Edward RB McCabe, MD, PhD

Physician-in-Chief,

Mattel Children’s Hospital at UCLA

Co-Director,

UCLA Center for Society and Genetics

www.socgen.ucla.edu

science of reproductive cloning
Science of Reproductive Cloning
  • What is a clone?
  • How is a clone created?
  • What is the difference between therapeutic and reproductive cloning?
  • Why clone animals and humans?
  • What types of animals have been cloned and what have we observed?
  • Who is doing this research and where?
science of reproductive cloning3
Science of Reproductive Cloning
  • What is a clone?
  • How is a clone created?
  • What is the difference between therapeutic and reproductive cloning?
  • Why clone animals and humans?
  • What types of animals have been cloned and what have we observed?
  • Who is doing this research and where?
clone
Clone
  • A copy of
    • Gene
    • Animal
  • A clone of an animal
    • An exact genetic copy of the original
    • Equivalent to an identical twin
science of reproductive cloning5
Science of Reproductive Cloning
  • What is a clone?
  • How is a clone created?
  • What is the difference between therapeutic and reproductive cloning?
  • Why clone animals and humans?
  • What types of animals have been cloned and what have we observed?
  • Who is doing this research and where?
science of reproductive cloning8
Science of Reproductive Cloning
  • What is a clone?
  • How is a clone created?
  • What is the difference between therapeutic and reproductive cloning?
  • Why clone animals and humans?
  • What types of animals have been cloned and what have we observed?
  • Who is doing this research and where?
cloning
Cloning
  • Therapeutic
    • To generate stem cells for use in Regenerative Medicine
  • Reproductive
    • To generate clonal organism(s) from an original individual
embryonic stem cells
Embryonic Stem Cells
  • Generated from
  • inner cell mass (ICM)
  • of embryo
  • Pluripotent or totipotent –
  • any cell can give rise to a
  • complete organism
  • ES cells in culture growing
  • on spindle-shaped fibroblast
  • feeder layer
  • Will differentiate into embryoid
  • bodies in culture
science of reproductive cloning12
Science of Reproductive Cloning
  • What is a clone?
  • How is a clone created?
  • What is the difference between therapeutic and reproductive cloning?
  • Why clone animals and humans?
  • What types of animals have been cloned and what have we observed?
  • Who is doing this research and where?
why clone animals
Why Clone Animals?
  • To generate protein therapeutics that are highly and reproducibly expressed from animal to animal
  • To be used to develop organs for transplantation into humans
  • To save endangered species from distinction
  • To reproduce desirable characteristics, such as speed in a race horse
    • To permit infertile animals with desirable features to reproduce
slide14

Funny Cide

2003

Kentucky Derby

Taz

Champion Racing Mule

Preakness

Idaho Gem

Cloned from

Fetal Sib of

Taz

why clone humans
Why Clone Humans?
  • To obtain human embryonic stem cells (hESCs) for Regenerative Medicine
  • To generate an identical twin of an existing or previously existing individual
  • To engineer the clone of an individual with a genetic disorder such that the clone would be identical except for the “repaired” gene
why are cloning and embryonic stem cells linked
Why Are Cloning and Embryonic Stem Cells Linked?
  • ES cells could be derived from donated, or “abandoned” or “orphaned” embryos
  • For transplantation of immunologically identical tissue
    • ES cells could be derived using SCNT from the individual who would receive the ES cell-derived tissue
science of reproductive cloning18
Science of Reproductive Cloning
  • What is a clone?
  • How is a clone created?
  • What is the difference between therapeutic and reproductive cloning?
  • Why clone animals and humans?
  • What types of animals have been cloned and what have we observed?
  • Who is doing this research and where?
slide19

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observations in cloned animals
Observations in Cloned Animals
  • Extremely low reproductive efficiency
  • High late fetal losses
  • Placental abnormalities
  • Increased birth size
    • Large offspring syndrome
      • Risk to mother and offspring
  • High early neonatal death rates
    • Respiratory deaths
science of reproductive cloning21
Science of Reproductive Cloning
  • What is a clone?
  • How is a clone created?
  • What is the difference between therapeutic and reproductive cloning?
  • Why clone animals and humans?
  • What types of animals have been cloned and what have we observed?
  • Who is doing this research and where?
summary
Summary
  • What is a clone?
  • How is a clone created?
  • What is the difference between therapeutic and reproductive cloning?
  • Why clone animals and humans?
  • What types of animals have been cloned and what have we observed?
  • Who is doing this research and where?