Characterization of Gene Expression Profiles from Drug-Induced Liver Injury  Ching-Wei Chang and James J. Chen NCTR Preloader

Characterization of Gene Expression Profiles from Drug-Induced Liver Injury Ching-Wei Chang and James J. Chen NCTR - PowerPoint PPT Presentation


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Background: Drug-induced liver injury (Hepatotoxicity) Liver Toxicity Biomarkers Study: Drug pair, tolcapone and entacapone Methods: Design and marker identification strategy Results: Validation (statistics)Susceptible Animals: Clinical variablesSummary. Outline . Background. Hepatotoxicity accounts for ~27% of drugs withdrawn from the market in the period 1960-2002.Hepatotoxicity accounts for over 40% of drug candidate terminations in the clinical phase.An estimate cost due to hepa1140

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