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Tagrisso 40mg tablet | osimertinib | Apple pharmaceuticals

Tagrisso 40mg (osimertinib) tablet is containing an active substance known as Osimeritinib,which is formerly known as Mereletinib.Buy Tagrisso 40mg tablet @ Apple Pharmaceuticals<br>

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Tagrisso 40mg tablet | osimertinib | Apple pharmaceuticals

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  1. Tagrisso 40mg tablet | osimertinib 40mg Apple pharmaceuticals

  2. Tagrisso 40mg tablet (osimertinib) A Tagrisso 40 mg tablet is containing an active substance known as Osimeritinib, which is formerly known as Mereletinib. Tagrisso 40mg is considered as third generation medicine, which is available in tablet form.  Tagrisso 40mg tablet is an inevitable, selectively deviated epidermal growth factor receptor prohibitor, containing anti-cancer activity.  The pharmacological category of Tagrisso 40mgis tyrosine kinase prohibitor.

  3. INDICATION ATagrisso 40mg (osimertinib) tablet is widely indicated as first line therapy for advanced non-small cell lung cancer with EGFR mutation positive patients. Tagrisso 40mg is also used for the treatment of patients affected with advanced EGFR T792M mutation positive NSCLC, disease has advanced on or after the tyrosine kinase inhibitor treatment.

  4. DOSAGE The usual prescribed dosage of Tagrisso tablets are, 80mg tablet should be taken as a single dose .Tagrisso 40mg tablet should be administered with or without food. If patient felt difficult to swallow the Tagrisso 40mg tablets as such, must disperse the tablet in 60ml of noncarbonated water and drink the solution immediately. Tagrisso tablet do not break, crush or chew.

  5. ADME Absorption: Peak plasma concentration time of osimertinib reaches within 6 hours Distribution:Volumeof distribution 918L Plasma protein bound to Osimeritinib is 95% Metabolism : The metabolism of Osimeritinib is occurs through oxidation. The Two pharmacologically active metabolite of Osimeritinib are AZ7550 & AZ5104

  6. MECHANISM Osimeritinib is similar in action when compared to other tyrosine kinase inhibitor drugs.  Osimeritinib 40mg is named tyrosine kinase inhibitor of epidermal development factor receptor which is available on the surface of tumor cells Osimeritinib is non-reversibly converge with mutant type of EGFR at 9 folds than wild sort 

  7. PRECAUTION Some of the adverse effects occur during the therapy : Interstitial lung disease: To avoid this problem, withheld or discontinue the Tagrisso 40mg tablet. QTcextension: Avoid concurrent use of Tagrisso 40mg with drug prolong the QTc Cardiomyopathy: Periodic cardiac monitoring is assessed; in this condition discontinue the therapy.

  8. DRUG INTERACTION Tagrisso 40mg tablet combines with strong CYP3A4 inducers causes reducing the exposure of Osimeritinib, this may leads to reduce the efficacy of Tagrisso. Avoid the concomitant use of strong CYP3A4 inducers with Tagrisso 40mg tablets. Tagrisso 40mg tablet combined with BCRP substrates may causes increasing the exposure of BCRP substrates. Thus results as increasing the adverse effects related to BCRP substrates 

  9. CONTRAINDICATION No contraindication occurred during the therapy In some patient’s anaphylactic reaction may occur due to patients may contraindicated to the ingredient of the product Tagrisso 40mg is a chemo medicine, in case of missed dose occurred skip the missed dose and follow the regular dosing schedule.

  10. SIDE EFFECTS Common side effects : Fatigue; Lymphocytopenia (Low White Blood Cells); Low Sodium; Shortness of breath; Musculoskeletal Pain; Decreased Appetite; Cough Less common side effects : Constipation; Increased serum creatinine; Colitis; Low potassium; Low magnesium; High calcium; Vomiting; Weakness; Diarrhea; High potassium; Low calcium; Swelling; Fever; Rash; Abdominal pain; Increased serum AST; Thrombocytopenia; Increased serum alkaline phosphatase; Chest pain; Weight loss.This are the tagrisso side effects.

  11. Contact Us phone No      :9987711567 Email             :info@myapplepharma.com website https://myapplepharma.com/osimeritinib-40mg.php

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