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Traditional practices in South Africa. Vanessa Steenkamp Department of Pharmacology University of Pretoria. 200 000 healers 80% population. Callilepis laureola DC. Ox-eye daisy Impila . Decongestant Induce fertility Ward off “evil spirits”. Atractyloside Carboxyatractyloside
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South Africa
Vanessa Steenkamp
Department of Pharmacology
University of Pretoria
80% population
Carboxyatractyloside
Inhibits transport of ADP
into mitochondria
No synthesis of ATP
Cell death
Presentation:
Hepatocellular failure
Nephrotoxicity
80% confused/ coma
95% hypoglycaemia
87% metabolic acidosis
(pyrrolizidine alkaloid)
Damages vascular
endothelium
VOD
Presentation
96% ascites
85% hepatomegaly
92% liver enzymes
Digitalis-like effect
AV block
Rhythm disturbance
Presentation
Gastrointestinal symptoms
Nausea
Vomiting
Cape aloe
T: Laxative
Arthritis
Eczema
Conjuctivitis
Hypertension
Stress
Wounds
C: laxative
(Berg.) Pill.
Buchu
T:stomach complaints
kidney
urinary tract
rheumatism
C: urinary tract
Fisch. & CA Mey.
African potato
T: Emetics, dizziness
Bladder disorders
Insanity
Prostate problems
C: BPH
Urinary infections
Sutherlandia frutescens (L.)R. Br.
Cancer bush
T: Cancer
gastric ailments
oedema
blood purifier
C: general health
tonic
L-arginine antagonist
Anticancer
Antiviral
Pinitol – anti-diabetic agent
GABA:- inhibitory neurotransmitter – anxiety and stress
- Toxicity in vervet monkeys: biochemical, haematological,
- physiological and physical variables : Seier et al. 2002
- Analgesic, anti-inflammatory, hypoglycemic effects:
- Ojewole 2004
- Antioxidant potential: Fernandes et al. 2004
- Effect on COX-2 expression: Kundu et al. 2005
- Anti-HIV activities: Harnett et al. 2005
Sutherlandia has earned the reputation of
being an excellent tonic for bringing about
a general feeling of wellbeing and calmness,
for boosting the immune system and
bolstering energy levels during illness or
convalescence.
Indigenous systems of medicine
are dynamic and adaptive,
although firmly rooted in the
traditions of the past.
This is evident from the
incorporation of medical herbs
into materica medica.
