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Bone marrow transplant (BMT) also called as hematopoietic stem cell transplant (HSCT) is the procedure that is used to replace the unhealthy bone marrow with new and healthy bone marrow. Bone marrow is the soft, fatty tissue inside the bones that is responsible for the production of blood cells. There are several medical conditions due to which the bone marrow become dysfunctional and therefore needs to be replaced. Further there are multiple types of Bone Marrow Transplants based on the donor of the bone marrow or stem cells.
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He has completed MBBS from Government Medical College, Nagpur, which is one of the largest Medical College and Hospital in Asia. Thereafter he did his postgraduation in Paediatrics from Seth GSMC & KEM hospital Mumbai, which has word wide reputation as one of the best teaching Hospital. He completed DNB Paediatrics from Southern Railway Headquarter Hospital, Chennai. He did Fellowship of National Board (FNB) in Paediatric Haematology, Oncology & BMT from Sir Gangaram Hospital, New Delhi, India which is recognised as one of the premier institute and hospital worldwide.
Bone Marrow Bone marrow is a spongy substance found in the center of the bones. It manufactures bone marrow stem cells and other substances, which in turn produce blood cells. Each type of blood cell made by the bone marrow has an important job. Red blood cells carry oxygen to tissues in the body. Platelets stop bleeding by helping blood clot. White blood cells fight infections.
White Blood Cell Three very important types of white blood cells are essential to the proper functioning of the body's immune system, which fights infection: Neutrophils and Macrophages Lymphocytes
Neutrophils and Macrophages — These white blood cells fight bacterial and fungal infections by "eating" germs Lymphocytes — These white blood cells fight bacterial, viral and fungal infections. T lymphocytes, also called T cells, attack viruses and other germs. T cells from the donor also can attack the recipient resulting in a reaction called graft versus host disease. T cells from the recipient can reject the donor bone marrow cell resulting in graft failure. B lymphocytes make antibodies which help destroy germs in our body.
Alternative Sources of Bone Marrow Stem Cells Another source of bone marrow stem cells is the blood that circulates in the veins and arteries of all normal people. These stem cells are known as peripheral blood stem cells (PBSC). Patients recovering from chemotherapy and healthy people who are treated with certain drugs that stimulate the growth of the bone marrow have relatively large numbers of PBSC in their blood. The PBSC can be collected and used in certain situations as a source of stem cells for transplantation.
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