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Neuroendocrine tumours (NETs) are a unique group of cancers that originate from neuroendocrine cells u2014 specialized cells with features of both nerve cells and hormone-producing cells. These tumours can develop in various parts of the body, most commonly in the gastrointestinal tract, pancreas, and lungs. Although often slow-growing, some NETs can be aggressive and require timely medical evaluation and treatment.
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Neuroendocrine Tumours (NETs) By Dr. Sachin Arora, MBBS, MS, M.Ch. (Surgical Gastroenterologist) Neuroendocrine tumours (NETs) are a unique group of cancers that originate from neuroendocrine cells — specialized cells with features of both nerve cells and hormone-producing cells. These tumours can develop in various parts of the body, most commonly in the gastrointestinal tract, pancreas, and lungs. Although often slow-growing, some NETs can be aggressive and require timely medical evaluation and treatment.
Understanding Neuroendocrine Tumours Neuroendocrine cells play a crucial role in regulating numerous bodily functions by releasing hormones into the bloodstream. When these cells begin to grow abnormally, they form neuroendocrine tumours, which may secrete excessive hormones, causing a range of systemic symptoms. A common type of NET is the Carcinoid Tumour, typically found in the intestines, lungs, or other parts of the digestive system. These tumours can sometimes spread (metastasize) to other organs, such as the liver, making early detection vital. Common Symptoms Symptoms of neuroendocrine tumours vary depending on the tumour’s location and whether it produces hormones. Often, early stages may go unnoticed. However, key warning signs include: Abdominal pain: Persistent or intermittent pain due to tumour growth or intestinal obstruction. Diarrhea or digestive issues: Caused by excessive hormone release affecting bowel movement. Flushing of the skin: Sudden redness or warmth, especially on the face and neck, due to hormone secretion. Unexplained weight loss: Caused by metabolic changes and poor nutrient absorption. Hormonal changes: Manifested through irregularities in metabolism, mood, and general health. These symptoms can mimic other digestive conditions, making expert evaluation essential for accurate diagnosis.
Diagnosis Diagnosis of NETs typically involves a combination of: Imaging tests: CT scan, MRI, and PET scans to detect the tumour and assess spread. Endoscopic procedures: Visualization and biopsy of gastrointestinal lesions. Blood and urine tests: Measurement of hormone levels and tumour markers such as chromogranin A. Histopathological analysis: To determine tumour type, grade, and aggressiveness. Treatment Options Treatment for neuroendocrine tumours depends on tumour size, location, spread, and hormone activity. A multidisciplinary approach ensures the best outcomes. Surgery (Laparoscopic Removal): Whenever feasible, surgical excision remains the most effective treatment for localized NETs. Minimally invasive laparoscopic surgery offers faster recovery, less pain, and better cosmetic outcomes. Targeted Therapy and Chemotherapy: In advanced or metastatic cases, targeted therapy drugs and chemotherapy are used to inhibit tumour growth and control hormone production. Hormone-Controlling Medicines: Medications such as somatostatin analogues help manage symptoms like flushing and diarrhea by reducing hormone secretion. Regular Follow-up and Imaging: Continuous monitoring with imaging and lab tests ensures early detection of recurrence or metastasis.
Comprehensive Care Approach Managing NETs requires expert coordination between surgeons, oncologists, radiologists, and endocrinologists. The goal is not only to remove the tumour but also to improve quality of life and manage hormone-related symptoms. At Dr. Sachin Arora’s Surgical Gastroenterology practice, patients receive personalized care combining advanced diagnostics, minimally invasive surgical techniques, and evidence-based medical therapy. Why Choose Dr. Sachin Arora Dr. Sachin Arora is a highly skilled Laparoscopic Gastrointestinal, HPB (Hepato- Pancreato-Biliary), and Gastrointestinal Cancer Surgeon with extensive experience in managing complex abdominal and hepatobiliary disorders. He specializes in laparoscopic and robotic surgery for gastrointestinal and neuroendocrine tumours, ensuring safe, precise, and effective treatment outcomes. Contact & Consultation For expert consultation and treatment of Neuroendocrine Tumours, Contact: Address:- GEIMS, 16th Milestone, Chakrata Road, Dehradun (UK) Sanjay Medicos, Ballupur Chowk, Dehradun (UK) Mobile :- +91 7505209117 Website :- https://drsachinarora.in/ Early detection and timely intervention are key to successful management of Neuroendocrine Tumours. If you experience persistent digestive or hormonal symptoms, consult a qualified gastroenterologist without delay.