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Cervical Cancer. By:Marisela Esparza. Cervical Cancer is cancer in the cervix (the lower part of the cervix that connects to the vagina.) . Causes: Abnormal Change in tissue. Human Papillomavirus There are 80 types of HPV Transmitted Sexually Cause 90% of Cervical Cancer

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cervical cancer

Cervical Cancer

By:Marisela Esparza

slide3
Cervical Cancer is cancer in the cervix (the lower part of the cervix that connects to the vagina.)
causes abnormal change in tissue
Causes: Abnormal Change in tissue
  • Human Papillomavirus
  • There are 80 types of HPV
  • Transmitted Sexually
  • Cause 90% of Cervical Cancer
  • Cause Genital Warts
symptoms
Symptoms
  • Unusual Vaginal Discharge
  • Bleeding or “spotting” outside of menstruation
  • Pain or vaginal bleeding during sexual intercourse
  • Post- menopausal bleeding
  • Pain during urination
  • Pelvic Pain
risk factors
Risk Factors
  • Unprotected Sex
  • Multiple Sex partners
  • Using Oral Contraceptives
  • Immunosuppression
  • Smoking
  • Chlamydia
treatment
Treatment
  • Radiation
  • Surgery
  • Chemotherapy
  • New drugs still on clinical trials
prevention
Prevention
  • Vaccines (Gradasil, Cervarix)
  • Protected Sex
  • Regular Pap Tests
scientific article
Scientific Article

Human papilloma vaccines launch a era of cervical cancer prevention.

This was a study to see which vaccine was better gardasil or ceravix

slide10
Table 1: Characteristics of the HPV vaccines Gardasil and Cervarix

Characteristic Gardasil Cervarix

Manufacturer Merck Frosst Canada Ltd. GlaxoSmithKline Inc.

Type Prophylactic vaccine Prophylactic vaccine

consisting of virus-like consisting of virus-like

particles containing L1 particles containing L1

capsid proteins capsid proteins

Antigens Quadrivalent vaccine: Bivalent vaccine:

HPV types 6 HPV types

(20 [micro]g/dose), 16 (20 [micro]g/dose) and

11 (40 [micro]g/dose), 18 (20 [micro]g/dose)

16 (40 [micro]g/dose) and

18 (20 [micro]g/dose)

Antigen Yeast Baculovirus

expression

system

Adjuvant Alum: ASO4:

225 [micro]g aluminum 500 [micro]g aluminum

hydroxyphosphate sulfate hydroxide and 50 [micro]g

3-deacylated

monophosphoryl lipid A

Dose and 0.5 mL intramuscular 0.5 mL intramuscular

schedule injection at 0, 2 and injection at 0, 1 and

6 months 6 months

Availability Approved for sale Not yet available

in Canada

slide11
Table 2: Immune response and disease outcomes* for the HPV vaccines

Gardasil and Ceravix

Variable Gardasil Cervarix

Published trial * Phase 2 and 3 * Phase 2 and 3

results trials (21-27) trials (28-31)

Sample size * 20 583 (27) * 18 644 (31)

Maximum duration of * 5 years * 5.5 years

follow-up (phase 2) (23) (phase 2) (30)

* 3 years * 1.25

(phase 3) (25) (phase 3) (31)

Immune response 1 * Over 99% * Over 99%

month after seroconversion seroconversion

completion of

vaccine series * Antibody titres 11 * Antibody titres 107

times (HPV type 6), times (HPV type 16)

7 times (HPV type and 82 times (HPV

11), 105 times (HPV type 18) higher

type 16) and 19 than titres

times (HPV type 18) following natural

higher than titres infection (28)

following natural

HPV infection (22)

Duration of immune * 96% seropositive to * 100% seropositive to

response HPV types 6, 11 and HPV types 16 and 18

16 at 24 months at 51-53 months29

* 68% seropositive to

HPV type 18 at 24

months (25)

Persistent * Vaccine efficacy * Vaccine efficacy

infection ([dagger]) 93.5% (95% CI 80.4% (95% CI

from HPV types 16 83%-98%) (23) 70%-87%) (31)

and 18

Cervical * Vaccine efficacy * Vaccine efficacy

intraepithelial 98% (95% CI 90.4% (95% CI

neoplasia (grade 2 93%-100%) (27) 53%-99%) (31)

or higher) related

to HPV types 16

and 18

Vaginal and vulvar * Vaccine efficacy * No data

intraepithelial 97% (95% CI

neoplasia (grade 2 79%-100%) (26)

or higher) related

to HPV types 16

and 18

Persistent * No data * Vaccine efficacy

infection ([dagger]) 59.9% (95% CI

of HPV type 45 3%-85%) (31)

Persistent * No data * Vaccine efficacy

infection ([dagger]) 36.1% (95% CI

of HPV type 31 0.5%-60%) (31)

Protection from * Vaccine efficacy * No data

genital warts 96% (95% CI

86%-99%) (24)

video http www youtube com watch v 6ykwpffyr6c http www becervixsavvy co uk index html
Video http://www.youtube.com/watch?v=6YKwPfFYR6chttp://www.becervixsavvy.co.uk/index.html
works cited
Works Cited
  • Gale Encyclopedia of Cancer # 2
  • Gale cengage Learning

http://findgalegroup.com/ips/retrieve.do?cententSet=IAC-documents

Fred Hutchinson Cancer Research Center

http://fhcrc.org/reseach/disease/cervical_cancer/iindex.html

Cervical Cancer: information at gargasil.com

  • National Cancer Institute
  • http://www.cancer.gov/cancertopics/types/cervical
  • National Cervical Cancer Coalition
  • http://www.nccc-online.org/
  • American Cancer Society
  • http://www.cancer.org/docroot/CRI/content/CRI_2_4_1X_What_is_cervical_cancer_8.asp
pictures
Pictures
  • http://keetsa.com/blog/eco-friendly/vegan-condoms-by-glyde/
  • www.dailymail.co.uk
  • www.britannica.com