Misunderstanding of Peptide Synthesis
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Animals are proved potential for improving human health

Misunderstanding of Peptide Synthesis

Since 1963, Merrifield has successfully developed solid phase peptide synthesis (SPPS) method,

and through continuous improvement & perfection, nowadays this method has become a common

technology used in modern peptide and protein synthesis including Bivalirudin and glycopeptides

synthesis. Generally, many common units can obtain synthetic peptides rely on ready-made

peptides synthesis scheme, such as solid-phase synthesis, liquid-phase synthesis, as well as

large-scale peptide production.

Technically, one usual way to produce such peptides is to buy amino acids from some of the

world’s fine chemical plant production groups as raw materials targeted synthesis of a single

peptide. As pharmaceutical raw materials intermediates, these peptides are usually used in western

medicine formulations to enhance efficacy and improve the body’s absorption rate of drugs and

absorption rate.

In fifties and sixties of last century, peptides are mainly from animal organs. Taking thymosin as

an example, its production method is to cut off the newly born calf’s thymus and then use the

shock separation of biotechnology to separate the calf thymus peptides, while the final step is to

make the thymosin injection. This thymosin is mainly used for human immunity. At present, such

peptide has been out of state due to popular mad cow disease. This virus can engulf the animal

protein in the brain, destroying its brain tissue, cells and nerves. Therefore, other peptides like

Angiotensin II has been payed attention in recent years.

Once the human body get infected with this virus, it is more terrible than cancer because such

patients will ultimately become vegetative or die very soon. There are also peptides extracted from

human blood, whose side effects are also great. These peptides not only make the body infected

with hepatitis A, hepatitis B, hepatitis C, hepatitis, HIV but also form rejection of allergic


For the novice, gaining understanding on the principle of a certain peptide synthesis and specific

process as well as eliminating the problems encountered could be extremely necessary. In simple

terms, the most basic procedure of peptide synthesis process is nothing more than resin swelling,

deprotection, coupling, and then deprotection, and then coupling ...

Other special synthesis is established on the basis, but there are several errors to note during the

peptide synthesis for mass novice:

1. Omnipotent Peptide Cleavage Reagent

Most of the peptides can be cleaved from the resin by a combination of cleavage peptides, and this

is often necessary for amino acids with specific side chain protection. For polypeptide sequences

without side chain protection, 98% TFAand 2% water solution can be completed; the flexibility to

use a combination of cut peptide reagents should be payed enough concerns.

2.Amino acid’s side chain protection is the same.

Basic amino acids with active side chains need to be protected in the synthesis, and depending on

Animals are proved potential for improving human health

the side chain, the protecting groups also have different choices. Selecting the appropriate

protective group can effectively reduce the difficulty of synthesis.

3. Over long Synthesis Process

The synthesis efficiency of each step in a short time can reach more than 99%, while long-time

reaction on the positive reaction yield is very limited, which could greatly increase side effects.

Therefore, it’s necessary to control the synthesis time as well.

In fact, esterification is a classical organic synthetic reaction; with the development of peptide

synthesis, much research work has been done in this field.

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