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smarca4

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

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smarca4

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  1. smarca4 smarca4 Official Full Name Official Full Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Background Background The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012] Synonyms Synonyms SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4; BRG1; SNF2; SWI2; MRD16; RTPS2; BAF190; SNF2L4; SNF2LB; hSNF2b; BAF190A; transcription activator BRG1; SNF2-beta; SNF2-like 4; protein BRG-1; nuclear protein GRB1; brahma protein-like 1; BRM/SWI2-related gene 1; homeotic gene regulator; protein brahma homolog 1; BRG1-associated factor 190A; sucrose nonfermenting-like 4; ATP-dependent helicase SMARCA4; mitotic growth and transcription activator; global transcription activator homologous sequence; Recombinant Recombinant Proteins Proteins  Assay Kits Assay Kits Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price SMARCA4- 1019H Recombinant Human SMARCA4 Sf 9 Insect cells Human N/A +Inquiry

  2. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price SMARCA4- 1910H Recombinant Human SMARCA4, GST- tagged E. coli Human GST +Inquiry SMARCA4- 1915H Recombinant Human SMARCA4, His- tagged E. coli Human His +Inquiry SMARCA4- 1916H Recombinant Human SMARCA4, GST- tagged E. coli Human GST +Inquiry SMARCA4- 197H Recombinant Human SMARCA4 Protein, GST-tagged E.coli Human GST +Inquiry SMARCA4- 198H Recombinant Human SMARCA4 Protein, His-tagged E.coli Human His +Inquiry SMARCA4- 27675TH Recombinant Human SMARCA4, His- tagged Baculovirus- Insect Cells Human His +Inquiry SMARCA4- 27676TH Recombinant Human SMARCA4 Human +Inquiry SMARCA4- 2804H Recombinant Human SMARCA4, GST- tagged E. coli Human GST +Inquiry

  3. Source Source (Host) (Host) Cat.# Cat.# Product name Product name Species Species Tag Tag Price Price SMARCA4-72H Recombinant Human SMARCA4, His&FLAG-tagged E. coli Human His/Flag +Inquiry SMARCA4- 15597M Recombinant Mouse SMARCA4 Protein Mammalian Cells Mouse His +Inquiry SMARCA4- 6616C Recombinant Chicken SMARCA4 Mammalian Cells Chicken His +Inquiry Involved Pathway SMARCA4 involved in several pathways and played different roles in them. We selected most pathways SMARCA4 participated on our site, such as Chromatin modifying enzymes, Chromatin organization, Direct p53 effectors, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMARCA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Name Pathway Related Protein Pathway Related Protein Chromatin modifying enzymes RUVBL2; PHF17; ING3; ARID2; KDM4D; ATXN7L3; CARM1; TADA2B; SUZ12B; SMARCE1 Chromatin organization MSL1A; KDM1B; BRPF1; GATAD2A; ANO9A; KAT7; SAP30L; ELP3; SMARCE1; SMARCB1B Direct p53 effectors PCBP4; DUSP5; ZNF385A; NDRG1; CSE1L; AIFM2; CTSD; DUSP1; CCNK; S100A2 Formation of the beta-catenin:TCF transactivating complex TLE4; H3F3D; PYGO1; TLE2; BCL9; LEO1; ASH2L; CDC73; TLE3B; H3F3B.1 Glucocorticoid receptor regulatory network KRT14; KRT5; SMARCA4; EGR1; KRT17; NR1I3; BGLAP; SMARCD1; POU2F1; CSN2 Integrated Breast Cancer Pathway USP38; UBE2F; GRN; USP15; GDI1; JAKMIP1; SMARCA4; AHR; BACH1; ALKBH1 Prostate Cancer

  4. NOXA1; CCNE2; Ar; NDRG1; MAPK3; PDGFB; SMARCD1; NKX3-1; MDM2; CCNE1 RMTs methylate histone arginines ARID2; ARID1A; SMARCA4; COPRS; SMARCC1B; PBRM1L; SMARCB1A; WDR77; SMARCA2; PRMT5 Protein Function SMARCA4 has several biochemical functions, for example, ATP binding, DNA polymerase binding, DNA-dependent ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMARCA4 itself. We selected most functions SMARCA4 had, and list some proteins which have the same functions with SMARCA4. You can find most of the proteins on our site. Function Function Related Protein Related Protein Function Function ATP binding Related Protein Related Protein ABCA13; PDIK1L; AK3; PFKFB2; TUT1; RTCA; PRKCH; NME1; ORC5; CSK Function Function DNA polymerase binding Related Protein Related Protein SMARCA4; RAD51; FANCD2; CDK2AP1; ACD; PCNA; HMGB1; LONP1; FANCI Function Function DNA-dependent ATPase activity Related Protein Related Protein SMARCAL1; MSH3; ERCC2; ERCC6; RAD51D; CHD8; DHX36; MSH4; DMC1; XRCC3 Function Function RNA polymerase I CORE element sequence-specific DNA binding Related Protein Related Protein BAZ2A; RRN3; TAF1B; TAF1C; SMARCB1; EFCAB11; PIH1D1; SMARCA4 Function Function contributes_to RNA polymerase II core promoter proximal region sequence-specific DNA binding Related Protein Related Protein MBD3; ACTB; ACTL6A; CHD4; SMARCC2; GATAD2B; SMARCB1; HDAC2; MTA2; HDAC1 Function Function contributes_to RNA polymerase II distal enhancer sequence- specific DNA binding Related Protein Related Protein SMARCC1; MTA2; MBD3; RBBP4; ACTL6A; GATAD2B; SMARCB1; SMARCA4; SMARCC2; HDAC2 Function Function RNA polymerase II transcription coactivator activity Related Protein Related Protein PHF17; SMARCA2; SOX12; SOX11; POU1F1; PRRX1; MED12; PSIP1; PITX2; SMARCA4 Function Function Tat protein binding Related Protein Related Protein TRIM32; NPM1; ACTB; MDFIC; SMARCB1; SMARCA4; GABARAPL1; DLL1 Function Function androgen receptor binding Related Protein Related Protein DDX5; PARK7; GRIP1; RNF14; WIPI1; PRPF6; TGFB1I1; NCOA1; CCNE1; FOXP1

  5. Function Function helicase activity Related Protein Related Protein DHX33; DHX58; SETX; DDX51; EP400; CHD6; SUPV3L1; MCM6L; MOV10B.2; HELZ Function Function lysine-acetylated histone binding Related Protein Related Protein TAF1; BAZ1B; BRD7; BRD2; ATAD2B; BAZ2A; BRD9; PHIP; BRD4; TAF1L Function Function contributes_to nucleosomal DNA binding Related Protei Related Protein n GATAD2B; MTA2; SMARCB1; MBD3; SMARCA4; SMARCE1; HDAC1; ACTB; SMARCC2; ACTL6A Function Function p53 binding Related Protein Related Protein BCL2L12; HTT; ZMAT3; PSME3; RCHY1; TP53; BANP; SMARCA4; EHMT2; TP63 Function Function protein N-terminus binding Related Protein Related Protein MEN1; TBL1XR1; PDLIM5; MECP2; ERCC2; PPP1CC; TAF11; SCT; SNF8; KCNIP1 Function Function protein binding Related Protein Related Protein OSTF1; SCIMP; MLPH; RBP7; MARCKSL1; NPHS1; NOMO2; DUSP5; MMP14; FBXL12 Function Function transcription coactivator activity Related Protein Related Protein CRSP7; ECD; CARM1; DDX17; YY1; ASXL1; MAK; TUBB3; CD3D; SNW1 Function Function transcription corepressor activity Related Protein Related Protein ZEB1; ALX1; ATF5; ANKRD1; ATF3; ZNF593; C1D; WNT4; ARHGAP35; HSF4 Function Function transcription factor binding Related Protein Related Protein MED1; ZFPM1; PRKDC; HEY1; FOXO4; JUN; CEBPA; PIAS2; MYBBP1A; ETS1 Interacting Protein SMARCA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMARCA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMARCA4. ARID1A

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