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HMTase (Histone methyltransferases) are histone-modifying enzymes, that catalyze the transfer of one, two, or three methyl teams to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at precise lysine or arginine residues on histones H3 and H4. Two major kinds of histone methyltranferases exist, lysine-precise and arginine-precise.
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