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definitions. Congenital megacolon HD is characterized by the absence of myenteric and submucosal ganglion cells in the distal alimentary tract; resulting in decreased motility in the affected bowel segment . Pathophysiology. Hirschsprung disease results from the absence of parasympathetic ganglion cells in the myenteric and submucosal plexus of the rectum and/or colon.Ganglion cells, which are derived from the neural crest, migrate caudally with the vagal nerve fibers along the intestine.The1141

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